%0 Journal Article
%A Oszlanczi, A.
%A Novak, Cs.
%A Klumpp, E.
%T Effects of Sulfadiazine on Biological Model Membranes
%J Journal of Thermal Analysis and Calorimetry
%V 82
%@ 1388-6150
%C Dordrecht [u.a.]
%I Springer Science + Business Media B.V
%M PreJuSER-48169
%P 457 - 462
%D 2005
%Z Record converted from VDB: 12.11.2012
%X The effect of sulfadiazine on dipalmitoylphosphatidylethanolamin-dipalmitoylphosphatidylglycerol-water (DPPE-DPPG/water, 20 mass/ mass%, with 0.2 DPPG/DPPE+DPPG molar ratio) vesicles considered as a model system of the cytoplasmic bacterial membranes was studied using DSC and freeze-fracture methods. The sulfadiazine/ lipid molar ratio was varied from 10(-3) up to 1. It was found that the DPPE-DPPG/water system is drastically affected by the sulfadiazine, but there is no concentration effect in a wide range of sulfadiazine/ lipid molar ratios from 10(-2) up to 2 center dot 10(-1). The DSC and freeze-fracture methods reveal that a homogeneous incorporation of the sulfadiazine molecules occurs in the liquid crystalline phase while in the gel phase separation appears. The different local structures can be classified into two different types: vesicle-like and block-type. Although the surface morphology of the domains of both types shows lamellar arrangement, the blocks are constituted from closely packed long units.
%K J (WoSType)
%F PUB:(DE-HGF)16
%9 Journal Article
%U <Go to ISI:>//WOS:000233043700025
%R 10.1007/s10973-005-0917-x
%U https://juser.fz-juelich.de/record/48169