Journal Article

PreJuSER-48169

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Effects of Sulfadiazine on Biological Model Membranes

Oszlanczi, A. ; Novak, C. ; Klumpp, E.FZJ*

2005
Springer Science + Business Media B.V Dordrecht [u.a.]

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Please use a persistent id in citations: doi:10.1007/s10973-005-0917-x

Abstract: The effect of sulfadiazine on dipalmitoylphosphatidylethanolamin-dipalmitoylphosphatidylglycerol-water (DPPE-DPPG/water, 20 mass/ mass%, with 0.2 DPPG/DPPE+DPPG molar ratio) vesicles considered as a model system of the cytoplasmic bacterial membranes was studied using DSC and freeze-fracture methods. The sulfadiazine/ lipid molar ratio was varied from 10(-3) up to 1. It was found that the DPPE-DPPG/water system is drastically affected by the sulfadiazine, but there is no concentration effect in a wide range of sulfadiazine/ lipid molar ratios from 10(-2) up to 2 center dot 10(-1). The DSC and freeze-fracture methods reveal that a homogeneous incorporation of the sulfadiazine molecules occurs in the liquid crystalline phase while in the gel phase separation appears. The different local structures can be classified into two different types: vesicle-like and block-type. Although the surface morphology of the domains of both types shows lamellar arrangement, the blocks are constituted from closely packed long units.

Keyword(s): J ; DPPE-DPPG vesicles (auto) ; DSC (auto) ; freeze-fracture (auto) ; phase separation (auto) ; sulfadiazine (auto)

Note: Record converted from VDB: 12.11.2012

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Contributing Institute(s):

1. Agrosphäre (ICG-IV)

Research Program(s):

1. Chemie und Dynamik der Geo-Biosphäre (U01)

Appears in the scientific report 2005

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Database coverage:
Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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