TY  - JOUR
AU  - Oszlanczi, A.
AU  - Novak, Cs.
AU  - Klumpp, E.
TI  - Effects of Sulfadiazine on Biological Model Membranes
JO  - Journal of Thermal Analysis and Calorimetry
VL  - 82
SN  - 1388-6150
CY  - Dordrecht [u.a.]
PB  - Springer Science + Business Media B.V
M1  - PreJuSER-48169
SP  - 457 - 462
PY  - 2005
N1  - Record converted from VDB: 12.11.2012
AB  - The effect of sulfadiazine on dipalmitoylphosphatidylethanolamin-dipalmitoylphosphatidylglycerol-water (DPPE-DPPG/water, 20 mass/ mass%, with 0.2 DPPG/DPPE+DPPG molar ratio) vesicles considered as a model system of the cytoplasmic bacterial membranes was studied using DSC and freeze-fracture methods. The sulfadiazine/ lipid molar ratio was varied from 10(-3) up to 1. It was found that the DPPE-DPPG/water system is drastically affected by the sulfadiazine, but there is no concentration effect in a wide range of sulfadiazine/ lipid molar ratios from 10(-2) up to 2 center dot 10(-1). The DSC and freeze-fracture methods reveal that a homogeneous incorporation of the sulfadiazine molecules occurs in the liquid crystalline phase while in the gel phase separation appears. The different local structures can be classified into two different types: vesicle-like and block-type. Although the surface morphology of the domains of both types shows lamellar arrangement, the blocks are constituted from closely packed long units.
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000233043700025
DO  - DOI:10.1007/s10973-005-0917-x
UR  - https://juser.fz-juelich.de/record/48169
ER  -