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@ARTICLE{Atanasov:48738,
      author       = {Atanasov, V. and Knorr, N. and Duran, R. S. and Ingebrandt,
                      S. and Offenhäusser, A. and Knoll, W. and Köper, I.},
      title        = {{M}embrane on a {C}hip. {A} functional tethered lipid
                      bilayer membrane on silicon oxide surface},
      journal      = {Biophysical journal},
      volume       = {89},
      issn         = {0006-3495},
      address      = {New York, NY},
      publisher    = {Rockefeller Univ. Press},
      reportid     = {PreJuSER-48738},
      pages        = {1780 - 1788},
      year         = {2005},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {Tethered membranes have been proven during recent years to
                      be a powerful and flexible biomimetic platform. We reported
                      in a previous article on the design of a new architecture
                      based on the self-assembly of a thiolipid on ultrasmooth
                      gold substrates, which shows extremely good electrical
                      sealing properties as well as functionality of a bilayer
                      membrane. Here, we describe the synthesis of lipids for a
                      more modular design and the adaptation of the linker part to
                      silane chemistry. We were able to form a functional tethered
                      bilayer lipid membrane with good electrical sealing
                      properties covering a silicon oxide surface. We demonstrate
                      the functional incorporation of the ion carrier valinomycin
                      and of the ion channel gramicidin.},
      keywords     = {Biophysics: methods / Electric Impedance / Electrochemistry
                      / Gold: chemistry / Gramicidin: pharmacology / Ion Channels:
                      chemistry / Ionophores: pharmacology / Ions / Lipid
                      Bilayers: chemistry / Lipid Bilayers: metabolism / Lipids:
                      chemistry / Microscopy, Atomic Force / Models, Chemical /
                      Phosphatidylcholines: chemistry / Phytol: chemistry /
                      Protein Array Analysis: methods / Silanes: chemistry /
                      Silanes: metabolism / Silicon: chemistry / Silicon Dioxide:
                      chemistry / Spectrophotometry / Substrate Specificity /
                      Temperature / Time Factors / Valinomycin: chemistry /
                      Valinomycin: pharmacology /
                      2,3-di-O-phytanyl-sn-glycerol-1-tetraethylene
                      glycol-(3-chloro-dimethylpropyl-silane) ether lipid (NLM
                      Chemicals) / 2,3-di-O-phytanyl-sn-glycerol-1-tetraethylene
                      glycol-(3-trichloropropyl-silane) ether lipid (NLM
                      Chemicals) / Ion Channels (NLM Chemicals) / Ionophores (NLM
                      Chemicals) / Ions (NLM Chemicals) / Lipid Bilayers (NLM
                      Chemicals) / Lipids (NLM Chemicals) / Phosphatidylcholines
                      (NLM Chemicals) / Silanes (NLM Chemicals) / Gramicidin (NLM
                      Chemicals) / Phytol (NLM Chemicals) / Valinomycin (NLM
                      Chemicals) / 1,2-diphytanoylphosphatidylcholine (NLM
                      Chemicals) / Silicon (NLM Chemicals) / Gold (NLM Chemicals)
                      / Silicon Dioxide (NLM Chemicals) / J (WoSType)},
      cin          = {CNI / ISG-2},
      ddc          = {570},
      cid          = {I:(DE-Juel1)VDB381 / I:(DE-Juel1)VDB42},
      pnm          = {Materialien, Prozesse und Bauelemente für die Mikro- und
                      Nanoelektronik},
      pid          = {G:(DE-Juel1)FUEK252},
      shelfmark    = {Biophysics},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:16127170},
      pmc          = {pmc:PMC1366681},
      UT           = {WOS:000231502800034},
      doi          = {10.1529/biophysj.105.061374},
      url          = {https://juser.fz-juelich.de/record/48738},
}