Journal Article

PreJuSER-48738

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Membrane on a Chip. A functional tethered lipid bilayer membrane on silicon oxide surface

Atanasov, V. ; Knorr, N. ; Duran, R. S. ; Ingebrandt, S.FZJ* ; Offenhäusser, A.FZJ* ; Knoll, W. ; Köper, I.

2005
Rockefeller Univ. Press New York, NY

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Please use a persistent id in citations: http://hdl.handle.net/2128/2125  doi:10.1529/biophysj.105.061374

Abstract: Tethered membranes have been proven during recent years to be a powerful and flexible biomimetic platform. We reported in a previous article on the design of a new architecture based on the self-assembly of a thiolipid on ultrasmooth gold substrates, which shows extremely good electrical sealing properties as well as functionality of a bilayer membrane. Here, we describe the synthesis of lipids for a more modular design and the adaptation of the linker part to silane chemistry. We were able to form a functional tethered bilayer lipid membrane with good electrical sealing properties covering a silicon oxide surface. We demonstrate the functional incorporation of the ion carrier valinomycin and of the ion channel gramicidin.

Keyword(s): Biophysics: methods (MeSH) ; Electric Impedance (MeSH) ; Electrochemistry (MeSH) ; Gold: chemistry (MeSH) ; Gramicidin: pharmacology (MeSH) ; Ion Channels: chemistry (MeSH) ; Ionophores: pharmacology (MeSH) ; Ions (MeSH) ; Lipid Bilayers: chemistry (MeSH) ; Lipid Bilayers: metabolism (MeSH) ; Lipids: chemistry (MeSH) ; Microscopy, Atomic Force (MeSH) ; Models, Chemical (MeSH) ; Phosphatidylcholines: chemistry (MeSH) ; Phytol: chemistry (MeSH) ; Protein Array Analysis: methods (MeSH) ; Silanes: chemistry (MeSH) ; Silanes: metabolism (MeSH) ; Silicon: chemistry (MeSH) ; Silicon Dioxide: chemistry (MeSH) ; Spectrophotometry (MeSH) ; Substrate Specificity (MeSH) ; Temperature (MeSH) ; Time Factors (MeSH) ; Valinomycin: chemistry (MeSH) ; Valinomycin: pharmacology (MeSH) ; 2,3-di-O-phytanyl-sn-glycerol-1-tetraethylene glycol-(3-chloro-dimethylpropyl-silane) ether lipid ; 2,3-di-O-phytanyl-sn-glycerol-1-tetraethylene glycol-(3-trichloropropyl-silane) ether lipid ; Ion Channels ; Ionophores ; Ions ; Lipid Bilayers ; Lipids ; Phosphatidylcholines ; Silanes ; Gramicidin ; Phytol ; Valinomycin ; 1,2-diphytanoylphosphatidylcholine ; Silicon ; Gold ; Silicon Dioxide ; J

Note: Record converted from VDB: 12.11.2012

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Contributing Institute(s):

1. Institut für Bio- und Chemosensoren (ISG-2)
2. Center of Nanoelectronic Systems for Information Technology (CNI)

Research Program(s):

1. Materialien, Prozesse und Bauelemente für die Mikro- und Nanoelektronik (I01)

Appears in the scientific report 2005
Notes: This version is available at the following Publisher URL: http://www.biophysj.org/

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