TY  - JOUR
AU  - Schügerl, K.
AU  - Hubbuch, J.
TI  - Integrated bioprocesses
JO  - Current opinion in microbiology
VL  - 8
SN  - 1369-5274
CY  - London
PB  - Current Biology Ltd.
M1  - PreJuSER-49743
SP  - 294 - 300
PY  - 2005
N1  - Record converted from VDB: 12.11.2012
AB  - Integrated bioprocesses have been developed to optimise yield and cost-effectiveness of production of low and high molecular weight molecules. Low molecular weight products are removed from the cultivation medium with in situ extraction, in situ adsorption or crystallisation to avoid product inhibition. One-pot processes are being developed to replace two-stage reactions. Recent developments in the integrated purification of high molecular weight products focus mainly on the integration of solid/liquid separation and initial product recovery such as expanded bed adsorption or extraction in aqueous two-phase systems. Additionally, new approaches for a more efficient processing of inclusion bodies have been developed.
KW  - Bacteria: metabolism
KW  - Biotechnology: methods
KW  - Industrial Microbiology: methods
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:15939352
UR  - <Go to ISI:>//WOS:000230098000009
DO  - DOI:10.1016/j.mib.2005.01.002
UR  - https://juser.fz-juelich.de/record/49743
ER  -