Journal Article

PreJuSER-49874

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png PROFASI: a Monte Carlo simulation package for protein folding and aggregation

Irbäck, A. ; Mohanty, S.FZJ*

2006
Wiley New York, NY [u.a.]

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Please use a persistent id in citations: doi:10.1002/jcc.20452

Abstract: We present a flexible and efficient program package written in C++, PROFASI, for simulating protein folding and aggregation. The systems are modeled using an all-atom description of the protein chains with only torsional degrees of freedom, and implicit water. The program package has a modular structure that makes the interaction potential easy to modify. The currently implemented potential is able to fold several peptides with about 20 residues, and has also been used to study aggregation and force-induced unfolding. The simulation methods implemented in PROFASI are Monte Carlo-based and include a semilocal move and simulated tempering. Adding new updates is easy. The code runs fast in both single- and multi-chain applications, as is illustrated by several examples.

Keyword(s): Algorithms (MeSH) ; Monte Carlo Method (MeSH) ; Protein Conformation (MeSH) ; Protein Folding (MeSH) ; J ; protein folding (auto) ; protein aggregation (auto) ; Monte Carlo (auto) ; all-atom model (auto) ; C plus (auto)

Note: Record converted from VDB: 12.11.2012

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Contributing Institute(s):

1. John von Neumann - Institut für Computing (NIC)

Research Program(s):

1. Scientific Computing (P41)

Appears in the scientific report 2006

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