Journal Article

PreJuSER-50364

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png A new method for radiochemical separation of arsenic from irradiated germanium oxide

Jennewein, M. ; Qaim, S. M.FZJ* ; Hermanne, A. ; Jahn, M. ; Tsyganov, E. ; Slavine, N. ; Seliounine, S. ; Antich, P. A. ; Kulkarni, P. V. ; Thorpe, P. E. ; Mason, R. P. ; Rösch, F.

2005
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.apradiso.2005.04.005

Abstract: Radioarsenic labelled radiopharmaceuticals could be a valuable asset to Positron Emission Tomography (PET). In particular, the long half-lives of (72)As (T(1/2)=26 h) and (74)As (T(1/2)=17.8 d) allow to investigate slow physiological or metabolical processes, like the enrichment and distribution of antibodies in tumor tissue. This work describes the direct production of no-carrier-added (nca) arsenic isotopes *As, with *=71, 72, 73, 74 or 77, the reaction to [*As]AsI(3) and its radiochemical separation from the irradiated solid germanium oxide via polystyrene-based solid-phase extraction. The germanium oxide target, irradiated at a cyclotron or a nuclear reactor, is dissolved in concentrated HF and Ge is separated almost quantitatively (99.97%) as [GeF(6)](2-). [*As]AsI(3) is formed by addition of potassium iodide. The radiochemical separation yield for arsenic is >90%. [*As]AsI(3) is a versatile radioarsenic labelling synthon.

Keyword(s): Arsenic: diagnostic use (MeSH) ; Arsenic: isolation & purification (MeSH) ; Germanium: chemistry (MeSH) ; Half-Life (MeSH) ; Positron-Emission Tomography: methods (MeSH) ; Radioisotopes: diagnostic use (MeSH) ; Radioisotopes: isolation & purification (MeSH) ; Radiopharmaceuticals: chemical synthesis (MeSH) ; Radiopharmaceuticals: diagnostic use (MeSH) ; Radioisotopes ; Radiopharmaceuticals ; germanium oxide ; Arsenic ; Germanium ; J ; As-71 (auto) ; As-72 (auto) ; As-73 (auto) ; As-74 (auto) ; As-77 (auto) ; radiochemical separation (auto) ; solid-phase extraction (auto)

Note: Record converted from VDB: 12.11.2012

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Contributing Institute(s):

1. Institut für Nuklearchemie (INC)

Research Program(s):

1. Neurowissenschaften (L01)

Appears in the scientific report 2005

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