001     5104
005     20180208201517.0
024 7 _ |2 pmid
|a pmid:19512925
024 7 _ |2 DOI
|a 10.1097/WCO.0b013e32832d95db
024 7 _ |2 WOS
|a WOS:000268380000001
037 _ _ |a PreJuSER-5104
041 _ _ |a eng
082 _ _ |a 610
084 _ _ |2 WoS
|a Clinical Neurology
084 _ _ |2 WoS
|a Neurosciences
100 1 _ |0 P:(DE-Juel1)131714
|a Zilles, K.
|b 0
|u FZJ
245 _ _ |a Receptor mapping: Architecture of the human cerebral cortex
260 _ _ |a London
|b Lippincott Williams & Wilkins
|c 2009
300 _ _ |a 331 - 339
336 7 _ |a Journal Article
|0 PUB:(DE-HGF)16
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336 7 _ |a Journal Article
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336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
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336 7 _ |a article
|2 DRIVER
440 _ 0 |0 12001
|a Current Opinion in Neurology
|v 22
|x 1350-7540
|y 4
500 _ _ |a The present study is supported by grants (K.Z., K.A.) from the Human Brain Project/Neuroinformatics Research funded by the National Institute of Biomedical Imaging and Bioengineering, the National Institute of Neurological Disorders and Stroke, and the National Institute of Mental Health and by a grant ('The Human Brain Model') to K.Z. from the Helmholtz Initiative on Systems Biology. Further support by the DFG (AM 118/1-2, K.A.) and the German Ministry for Education and Research (BMBF: BICVV to K.Z., 01GW0623 and 01GW0771 to K.A.) is acknowledged.
520 _ _ |a Cytoarchitectonical brain mapping is of growing interest as a powerful tool for localization of activated brain regions in functional neuroimaging. Mapping of neurotransmitter receptors can provide novel molecular and functionally relevant information to the available cytoarchitectonical brain maps, because receptors are key molecules of neurotransmission. This review highlights the relation between cytoarchitectonical parcellations and the regionally inhomogeneous distribution of receptors. It will demonstrate the potential of receptor mapping for novel and functionally relevant insights into the regional organization of the human cortex.Mapping of a single receptor type can already reveal borders of functionally and cytoarchitectonically distinct cortical regions. The combined mapping of various receptors in each cortical area (receptor fingerprint) represents the balance between different neurotransmitter systems and often reveals hitherto unknown parcellations. Different brain regions are identified as parts of distinct functional systems.Receptor mapping of the human brain, particularly multireceptor mapping, provides a novel and multimodal view of its anatomical, functional and molecular organization. It reveals organizational principles of the segregation of cortical and subcortical structures. It improves our understanding of the brain's architecture beyond the limits of cytoarchitectonics and serves as a basis for clinical and pharmacological studies of brain diseases.
536 _ _ |0 G:(DE-Juel1)FUEK409
|2 G:(DE-HGF)
|a Funktion und Dysfunktion des Nervensystems
|c P33
|x 0
588 _ _ |a Dataset connected to Web of Science, Pubmed
650 _ 2 |2 MeSH
|a Brain Mapping: methods
650 _ 2 |2 MeSH
|a Cerebral Cortex: anatomy & histology
650 _ 2 |2 MeSH
|a Cerebral Cortex: physiology
650 _ 2 |2 MeSH
|a Humans
650 _ 2 |2 MeSH
|a Receptors, Neurotransmitter: physiology
650 _ 7 |0 0
|2 NLM Chemicals
|a Receptors, Neurotransmitter
650 _ 7 |2 WoSType
|a J
653 2 0 |2 Author
|a cerebral cortex
653 2 0 |2 Author
|a human brain mapping
653 2 0 |2 Author
|a transmitter receptors
700 1 _ |0 P:(DE-Juel1)131631
|a Amunts, K.
|b 1
|u FZJ
773 _ _ |0 PERI:(DE-600)2026967-5
|a 10.1097/WCO.0b013e32832d95db
|g Vol. 22, p. 331 - 339
|p 331 - 339
|q 22<331 - 339
|t Current opinion in neurology
|v 22
|x 1350-7540
|y 2009
856 7 _ |u http://dx.doi.org/10.1097/WCO.0b013e32832d95db
909 C O |o oai:juser.fz-juelich.de:5104
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913 1 _ |0 G:(DE-Juel1)FUEK409
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914 1 _ |y 2009
915 _ _ |0 StatID:(DE-HGF)0010
|a JCR/ISI refereed
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