Journal Article

PreJuSER-5104

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Receptor mapping: Architecture of the human cerebral cortex

Zilles, K.FZJ* ; Amunts, K.FZJ*

2009
Lippincott Williams & Wilkins London

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Please use a persistent id in citations: doi:10.1097/WCO.0b013e32832d95db

Abstract: Cytoarchitectonical brain mapping is of growing interest as a powerful tool for localization of activated brain regions in functional neuroimaging. Mapping of neurotransmitter receptors can provide novel molecular and functionally relevant information to the available cytoarchitectonical brain maps, because receptors are key molecules of neurotransmission. This review highlights the relation between cytoarchitectonical parcellations and the regionally inhomogeneous distribution of receptors. It will demonstrate the potential of receptor mapping for novel and functionally relevant insights into the regional organization of the human cortex.Mapping of a single receptor type can already reveal borders of functionally and cytoarchitectonically distinct cortical regions. The combined mapping of various receptors in each cortical area (receptor fingerprint) represents the balance between different neurotransmitter systems and often reveals hitherto unknown parcellations. Different brain regions are identified as parts of distinct functional systems.Receptor mapping of the human brain, particularly multireceptor mapping, provides a novel and multimodal view of its anatomical, functional and molecular organization. It reveals organizational principles of the segregation of cortical and subcortical structures. It improves our understanding of the brain's architecture beyond the limits of cytoarchitectonics and serves as a basis for clinical and pharmacological studies of brain diseases.

Keyword(s): Brain Mapping: methods (MeSH) ; Cerebral Cortex: anatomy & histology (MeSH) ; Cerebral Cortex: physiology (MeSH) ; Humans (MeSH) ; Receptors, Neurotransmitter: physiology (MeSH) ; Receptors, Neurotransmitter ; J ; cerebral cortex (auto) ; human brain mapping (auto) ; transmitter receptors (auto)

Note: The present study is supported by grants (K.Z., K.A.) from the Human Brain Project/Neuroinformatics Research funded by the National Institute of Biomedical Imaging and Bioengineering, the National Institute of Neurological Disorders and Stroke, and the National Institute of Mental Health and by a grant ('The Human Brain Model') to K.Z. from the Helmholtz Initiative on Systems Biology. Further support by the DFG (AM 118/1-2, K.A.) and the German Ministry for Education and Research (BMBF: BICVV to K.Z., 01GW0623 and 01GW0771 to K.A.) is acknowledged.

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Contributing Institute(s):

1. Strukturelle und funktionelle Organisation des Gehirns (INM-1)
2. Molekulare Organisation des Gehirns (INM-2)
3. Jülich-Aachen Research Alliance - Translational Brain Medicine (JARA-BRAIN)

Research Program(s):

1. Funktion und Dysfunktion des Nervensystems (P33)

Appears in the scientific report 2009

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