TY  - JOUR
AU  - Stamelou, M.
AU  - Matusch, A.
AU  - Elmenhorst, D.
AU  - Hurlemann, R.
AU  - Eggert, K.M.
AU  - Zilles, K.
AU  - Oertel, W.H.
AU  - Höglinger, G.U.
AU  - Bauer, A.
TI  - Nigrostriatal Upregulation of 5-HT2A Receptors Correlates with Motor Dysfunction in Progressive Supranuclear Palsy
JO  - Movement disorders
VL  - 24
SN  - 0885-3185
CY  - New York, NY
PB  - Wiley InterScience
M1  - PreJuSER-5151
SP  - 1170 - 1175
PY  - 2009
N1  - This project was part of the Brain Imaging Center West (BICW) supported by the German Federal Ministry for Education and Research (BMBF, grant 01 G19934 to K.Z.), the Deutsche Forschungsgemeinschaft (DFG, Klinische Forschergruppe 112 to A.B.; HO2402/6-1 to G.H.), the International Consortium for Brain Mapping (ICBM grant to K.Z.), the Willy Robert Pitzer Foundation (to G.H./W.H.O.) and the von behringlrontgenlstiftung (56-0039 to G.H.).
AB  - A dysfunction of multiple neurotransmitter systems is assumed as a neurochemical basis of the akinetic-rigid syndrome of progressive supranuclear palsy (PSP). In vitro studies have produced conflicting results on the serotoninergic system in PSP. We, therefore, studied the binding potential of the serotonin 2A (5-HT(2A)) receptor ligand [18F]altanserin in 8 patients with clinically probable PSP and 13 healthy controls using positron emission tomography. We found an up-regulation of 5-HT(2A) receptors in the substantia nigra and, to a lower degree, in the striatum, while neocortical 5- HT(2A) receptor densities showed no changes upon partial-volume correction. Nigral and striatal receptor changes were significantly correlated with patients' scores of motor dysfunction (UPDRS III, PSP-rating scale) pointing to a functional relevance of the described findings.
KW  - Aged
KW  - Brain Mapping
KW  - Corpus Striatum: metabolism
KW  - Corpus Striatum: radionuclide imaging
KW  - Female
KW  - Fluorine Radioisotopes: metabolism
KW  - Humans
KW  - Ketanserin: analogs & derivatives
KW  - Ketanserin: metabolism
KW  - Magnetic Resonance Imaging: methods
KW  - Male
KW  - Middle Aged
KW  - Movement Disorders: etiology
KW  - Movement Disorders: pathology
KW  - Movement Disorders: radionuclide imaging
KW  - Positron-Emission Tomography: methods
KW  - Receptor, Serotonin, 5-HT2A: metabolism
KW  - Statistics as Topic
KW  - Substantia Nigra: metabolism
KW  - Substantia Nigra: radionuclide imaging
KW  - Supranuclear Palsy, Progressive: complications
KW  - Supranuclear Palsy, Progressive: radionuclide imaging
KW  - Up-Regulation: physiology
KW  - Fluorine Radioisotopes (NLM Chemicals)
KW  - Receptor, Serotonin, 5-HT2A (NLM Chemicals)
KW  - Ketanserin (NLM Chemicals)
KW  - altanserin (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:19353726
UR  - <Go to ISI:>//WOS:000267511000009
DO  - DOI:10.1002/mds.22533
UR  - https://juser.fz-juelich.de/record/5151
ER  -