Journal Article

PreJuSER-5151

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Nigrostriatal Upregulation of 5-HT2A Receptors Correlates with Motor Dysfunction in Progressive Supranuclear Palsy

Stamelou, M. ; Matusch, A.FZJ* ; Elmenhorst, D.FZJ* ; Hurlemann, R.FZJ* ; Eggert, K. M. ; Zilles, K.FZJ* ; Oertel, W. H. ; Höglinger, G. U. ; Bauer, A.FZJ*

2009
Wiley InterScience New York, NY

This record in other databases:    

Please use a persistent id in citations: doi:10.1002/mds.22533

Abstract: A dysfunction of multiple neurotransmitter systems is assumed as a neurochemical basis of the akinetic-rigid syndrome of progressive supranuclear palsy (PSP). In vitro studies have produced conflicting results on the serotoninergic system in PSP. We, therefore, studied the binding potential of the serotonin 2A (5-HT(2A)) receptor ligand [18F]altanserin in 8 patients with clinically probable PSP and 13 healthy controls using positron emission tomography. We found an up-regulation of 5-HT(2A) receptors in the substantia nigra and, to a lower degree, in the striatum, while neocortical 5- HT(2A) receptor densities showed no changes upon partial-volume correction. Nigral and striatal receptor changes were significantly correlated with patients' scores of motor dysfunction (UPDRS III, PSP-rating scale) pointing to a functional relevance of the described findings.

Keyword(s): Aged (MeSH) ; Brain Mapping (MeSH) ; Corpus Striatum: metabolism (MeSH) ; Corpus Striatum: radionuclide imaging (MeSH) ; Female (MeSH) ; Fluorine Radioisotopes: metabolism (MeSH) ; Humans (MeSH) ; Ketanserin: analogs & derivatives (MeSH) ; Ketanserin: metabolism (MeSH) ; Magnetic Resonance Imaging: methods (MeSH) ; Male (MeSH) ; Middle Aged (MeSH) ; Movement Disorders: etiology (MeSH) ; Movement Disorders: pathology (MeSH) ; Movement Disorders: radionuclide imaging (MeSH) ; Positron-Emission Tomography: methods (MeSH) ; Receptor, Serotonin, 5-HT2A: metabolism (MeSH) ; Statistics as Topic (MeSH) ; Substantia Nigra: metabolism (MeSH) ; Substantia Nigra: radionuclide imaging (MeSH) ; Supranuclear Palsy, Progressive: complications (MeSH) ; Supranuclear Palsy, Progressive: radionuclide imaging (MeSH) ; Up-Regulation: physiology (MeSH) ; Fluorine Radioisotopes ; Receptor, Serotonin, 5-HT2A ; Ketanserin ; altanserin ; J ; PSP (auto) ; Steele-Richardson-Olszewski syndrome (auto) ; serotonin (auto) ; 5-HT (auto) ; 5-HT2A receptor (auto) ; PET (auto)

Note: This project was part of the Brain Imaging Center West (BICW) supported by the German Federal Ministry for Education and Research (BMBF, grant 01 G19934 to K.Z.), the Deutsche Forschungsgemeinschaft (DFG, Klinische Forschergruppe 112 to A.B.; HO2402/6-1 to G.H.), the International Consortium for Brain Mapping (ICBM grant to K.Z.), the Willy Robert Pitzer Foundation (to G.H./W.H.O.) and the von behringlrontgenlstiftung (56-0039 to G.H.).

---

Contributing Institute(s):

1. Molekulare Organisation des Gehirns (INM-2)
2. Jülich-Aachen Research Alliance - Translational Brain Medicine (JARA-BRAIN)

Research Program(s):

1. Funktion und Dysfunktion des Nervensystems (P33)

Appears in the scientific report 2009

---