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@ARTICLE{Stamelou:5151,
      author       = {Stamelou, M. and Matusch, A. and Elmenhorst, D. and
                      Hurlemann, R. and Eggert, K.M. and Zilles, K. and Oertel,
                      W.H. and Höglinger, G.U. and Bauer, A.},
      title        = {{N}igrostriatal {U}pregulation of 5-{HT}2{A} {R}eceptors
                      {C}orrelates with {M}otor {D}ysfunction in {P}rogressive
                      {S}upranuclear {P}alsy},
      journal      = {Movement disorders},
      volume       = {24},
      issn         = {0885-3185},
      address      = {New York, NY},
      publisher    = {Wiley InterScience},
      reportid     = {PreJuSER-5151},
      pages        = {1170 - 1175},
      year         = {2009},
      note         = {This project was part of the Brain Imaging Center West
                      (BICW) supported by the German Federal Ministry for
                      Education and Research (BMBF, grant 01 G19934 to K.Z.), the
                      Deutsche Forschungsgemeinschaft (DFG, Klinische
                      Forschergruppe 112 to A.B.; HO2402/6-1 to G.H.), the
                      International Consortium for Brain Mapping (ICBM grant to
                      K.Z.), the Willy Robert Pitzer Foundation (to G.H./W.H.O.)
                      and the von behringlrontgenlstiftung (56-0039 to G.H.).},
      abstract     = {A dysfunction of multiple neurotransmitter systems is
                      assumed as a neurochemical basis of the akinetic-rigid
                      syndrome of progressive supranuclear palsy (PSP). In vitro
                      studies have produced conflicting results on the
                      serotoninergic system in PSP. We, therefore, studied the
                      binding potential of the serotonin 2A (5-HT(2A)) receptor
                      ligand [18F]altanserin in 8 patients with clinically
                      probable PSP and 13 healthy controls using positron emission
                      tomography. We found an up-regulation of 5-HT(2A) receptors
                      in the substantia nigra and, to a lower degree, in the
                      striatum, while neocortical 5- HT(2A) receptor densities
                      showed no changes upon partial-volume correction. Nigral and
                      striatal receptor changes were significantly correlated with
                      patients' scores of motor dysfunction (UPDRS III, PSP-rating
                      scale) pointing to a functional relevance of the described
                      findings.},
      keywords     = {Aged / Brain Mapping / Corpus Striatum: metabolism / Corpus
                      Striatum: radionuclide imaging / Female / Fluorine
                      Radioisotopes: metabolism / Humans / Ketanserin: analogs
                      $\&$ derivatives / Ketanserin: metabolism / Magnetic
                      Resonance Imaging: methods / Male / Middle Aged / Movement
                      Disorders: etiology / Movement Disorders: pathology /
                      Movement Disorders: radionuclide imaging / Positron-Emission
                      Tomography: methods / Receptor, Serotonin, 5-HT2A:
                      metabolism / Statistics as Topic / Substantia Nigra:
                      metabolism / Substantia Nigra: radionuclide imaging /
                      Supranuclear Palsy, Progressive: complications /
                      Supranuclear Palsy, Progressive: radionuclide imaging /
                      Up-Regulation: physiology / Fluorine Radioisotopes (NLM
                      Chemicals) / Receptor, Serotonin, 5-HT2A (NLM Chemicals) /
                      Ketanserin (NLM Chemicals) / altanserin (NLM Chemicals) / J
                      (WoSType)},
      cin          = {INM-2 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406 / $I:(DE-82)080010_20140620$},
      pnm          = {Funktion und Dysfunktion des Nervensystems},
      pid          = {G:(DE-Juel1)FUEK409},
      shelfmark    = {Clinical Neurology},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:19353726},
      UT           = {WOS:000267511000009},
      doi          = {10.1002/mds.22533},
      url          = {https://juser.fz-juelich.de/record/5151},
}