%0 Journal Article
%A Hamacher, K.
%A Coenen, H. H.
%T No-carrier-added nucleophilic 18F-labelling in an electrochemical cell exemplified by the routine production of [18F]altanserin
%J Applied radiation and isotopes
%V 64
%@ 0969-8043
%C Amsterdam [u.a.]
%I Elsevier Science
%M PreJuSER-54706
%P 989 - 994
%D 2006
%Z Record converted from VDB: 12.11.2012
%X A new type of electrochemical cell with anodic deposition of no-carrier-added [(18)F]fluoride and variable reaction volume has been developed. The reactor is designed for small reaction volumes and non-thermal drying of [(18)F]fluoride. The implementation of this reactor into a complete remotely controlled synthesis device is described for the routine production of [(18)F]altanserin. A radiochemical yield of 23+/-5% was obtained via cryptate-mediated nucleophilic (18)F-fluorination. Batches of up to 6 GBq [(18)F]altanserin, suitable for human application, with a molar activity of >500 GBq/micromol were obtained within 75 min.
%K Chromatography, High Pressure Liquid
%K Electrochemistry: instrumentation
%K Fluorine Radioisotopes
%K Isotope Labeling: methods
%K Ketanserin: analogs & derivatives
%K Ketanserin: chemistry
%K Ketanserin: isolation & purification
%K Fluorine Radioisotopes (NLM Chemicals)
%K Ketanserin (NLM Chemicals)
%K altanserin (NLM Chemicals)
%K J (WoSType)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:16829074
%U <Go to ISI:>//WOS:000240297300004
%R 10.1016/j.apradiso.2006.03.005
%U https://juser.fz-juelich.de/record/54706