Journal Article

PreJuSER-54706

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png No-carrier-added nucleophilic 18F-labelling in an electrochemical cell exemplified by the routine production of [18F]altanserin

Hamacher, K.FZJ* ; Coenen, H. H.FZJ*

2006
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.apradiso.2006.03.005

Abstract: A new type of electrochemical cell with anodic deposition of no-carrier-added [(18)F]fluoride and variable reaction volume has been developed. The reactor is designed for small reaction volumes and non-thermal drying of [(18)F]fluoride. The implementation of this reactor into a complete remotely controlled synthesis device is described for the routine production of [(18)F]altanserin. A radiochemical yield of 23+/-5% was obtained via cryptate-mediated nucleophilic (18)F-fluorination. Batches of up to 6 GBq [(18)F]altanserin, suitable for human application, with a molar activity of >500 GBq/micromol were obtained within 75 min.

Keyword(s): Chromatography, High Pressure Liquid (MeSH) ; Electrochemistry: instrumentation (MeSH) ; Fluorine Radioisotopes (MeSH) ; Isotope Labeling: methods (MeSH) ; Ketanserin: analogs & derivatives (MeSH) ; Ketanserin: chemistry (MeSH) ; Ketanserin: isolation & purification (MeSH) ; Fluorine Radioisotopes ; Ketanserin ; altanserin ; J ; electrochemical cell (auto) ; [F-18]altanserin (auto) ; nucleophilic F-18-fluorination (auto)

Note: Record converted from VDB: 12.11.2012

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Contributing Institute(s):

1. Institut für Nuklearchemie (INC)

Research Program(s):

1. Funktion und Dysfunktion des Nervensystems (P33)

Appears in the scientific report 2006

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