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000054706 0247_ $$2DOI$$a10.1016/j.apradiso.2006.03.005
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000054706 084__ $$2WoS$$aChemistry, Inorganic & Nuclear
000054706 084__ $$2WoS$$aNuclear Science & Technology
000054706 084__ $$2WoS$$aRadiology, Nuclear Medicine & Medical Imaging
000054706 1001_ $$0P:(DE-Juel1)VDB551$$aHamacher, K.$$b0$$uFZJ
000054706 245__ $$aNo-carrier-added nucleophilic 18F-labelling in an electrochemical cell exemplified by the routine production of [18F]altanserin
000054706 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2006
000054706 300__ $$a989 - 994
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000054706 440_0 $$0563$$aApplied Radiation and Isotopes$$v64$$x0969-8043
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000054706 520__ $$aA new type of electrochemical cell with anodic deposition of no-carrier-added [(18)F]fluoride and variable reaction volume has been developed. The reactor is designed for small reaction volumes and non-thermal drying of [(18)F]fluoride. The implementation of this reactor into a complete remotely controlled synthesis device is described for the routine production of [(18)F]altanserin. A radiochemical yield of 23+/-5% was obtained via cryptate-mediated nucleophilic (18)F-fluorination. Batches of up to 6 GBq [(18)F]altanserin, suitable for human application, with a molar activity of >500 GBq/micromol were obtained within 75 min.
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000054706 588__ $$aDataset connected to Web of Science, Pubmed
000054706 650_2 $$2MeSH$$aChromatography, High Pressure Liquid
000054706 650_2 $$2MeSH$$aElectrochemistry: instrumentation
000054706 650_2 $$2MeSH$$aFluorine Radioisotopes
000054706 650_2 $$2MeSH$$aIsotope Labeling: methods
000054706 650_2 $$2MeSH$$aKetanserin: analogs & derivatives
000054706 650_2 $$2MeSH$$aKetanserin: chemistry
000054706 650_2 $$2MeSH$$aKetanserin: isolation & purification
000054706 650_7 $$00$$2NLM Chemicals$$aFluorine Radioisotopes
000054706 650_7 $$074050-98-9$$2NLM Chemicals$$aKetanserin
000054706 650_7 $$076330-71-7$$2NLM Chemicals$$aaltanserin
000054706 650_7 $$2WoSType$$aJ
000054706 65320 $$2Author$$aelectrochemical cell
000054706 65320 $$2Author$$a[F-18]altanserin
000054706 65320 $$2Author$$anucleophilic F-18-fluorination
000054706 7001_ $$0P:(DE-Juel1)131816$$aCoenen, H. H.$$b1$$uFZJ
000054706 773__ $$0PERI:(DE-600)1499873-7$$a10.1016/j.apradiso.2006.03.005$$gVol. 64, p. 989 - 994$$p989 - 994$$q64<989 - 994$$tApplied radiation and isotopes$$v64$$x0969-8043$$y2006
000054706 8567_ $$uhttp://dx.doi.org/10.1016/j.apradiso.2006.03.005
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000054706 9141_ $$y2006
000054706 915__ $$0StatID:(DE-HGF)0010$$aJCR/ISI refereed
000054706 9201_ $$0I:(DE-Juel1)VDB53$$d31.12.2006$$gINC$$kINC$$lInstitut für Nuklearchemie$$x0
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