TY  - JOUR
AU  - Hamacher, K.
AU  - Coenen, H. H.
TI  - No-carrier-added nucleophilic 18F-labelling in an electrochemical cell exemplified by the routine production of [18F]altanserin
JO  - Applied radiation and isotopes
VL  - 64
SN  - 0969-8043
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - PreJuSER-54706
SP  - 989 - 994
PY  - 2006
N1  - Record converted from VDB: 12.11.2012
AB  - A new type of electrochemical cell with anodic deposition of no-carrier-added [(18)F]fluoride and variable reaction volume has been developed. The reactor is designed for small reaction volumes and non-thermal drying of [(18)F]fluoride. The implementation of this reactor into a complete remotely controlled synthesis device is described for the routine production of [(18)F]altanserin. A radiochemical yield of 23+/-5% was obtained via cryptate-mediated nucleophilic (18)F-fluorination. Batches of up to 6 GBq [(18)F]altanserin, suitable for human application, with a molar activity of >500 GBq/micromol were obtained within 75 min.
KW  - Chromatography, High Pressure Liquid
KW  - Electrochemistry: instrumentation
KW  - Fluorine Radioisotopes
KW  - Isotope Labeling: methods
KW  - Ketanserin: analogs & derivatives
KW  - Ketanserin: chemistry
KW  - Ketanserin: isolation & purification
KW  - Fluorine Radioisotopes (NLM Chemicals)
KW  - Ketanserin (NLM Chemicals)
KW  - altanserin (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:16829074
UR  - <Go to ISI:>//WOS:000240297300004
DO  - DOI:10.1016/j.apradiso.2006.03.005
UR  - https://juser.fz-juelich.de/record/54706
ER  -