Home > Publications database > No-carrier-added nucleophilic 18F-labelling in an electrochemical cell exemplified by the routine production of [18F]altanserin > print

001     54706
005     20190625112114.0
024 7 _ |2 pmid
|a pmid:16829074
024 7 _ |2 DOI
|a 10.1016/j.apradiso.2006.03.005
024 7 _ |2 WOS
|a WOS:000240297300004
024 7 _ |a altmetric:21816345
|2 altmetric
037 _ _ |a PreJuSER-54706
041 _ _ |a eng
082 _ _ |a 530
084 _ _ |2 WoS
|a Chemistry, Inorganic & Nuclear
084 _ _ |2 WoS
|a Nuclear Science & Technology
084 _ _ |2 WoS
|a Radiology, Nuclear Medicine & Medical Imaging
100 1 _ |a Hamacher, K.
|b 0
|u FZJ
|0 P:(DE-Juel1)VDB551
245 _ _ |a No-carrier-added nucleophilic 18F-labelling in an electrochemical cell exemplified by the routine production of [18F]altanserin
260 _ _ |a Amsterdam [u.a.]
|b Elsevier Science
|c 2006
300 _ _ |a 989 - 994
336 7 _ |a Journal Article
|0 PUB:(DE-HGF)16
|2 PUB:(DE-HGF)
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|0 0
|2 EndNote
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a article
|2 DRIVER
440 _ 0 |a Applied Radiation and Isotopes
|x 0969-8043
|0 563
|v 64
500 _ _ |a Record converted from VDB: 12.11.2012
520 _ _ |a A new type of electrochemical cell with anodic deposition of no-carrier-added [(18)F]fluoride and variable reaction volume has been developed. The reactor is designed for small reaction volumes and non-thermal drying of [(18)F]fluoride. The implementation of this reactor into a complete remotely controlled synthesis device is described for the routine production of [(18)F]altanserin. A radiochemical yield of 23+/-5% was obtained via cryptate-mediated nucleophilic (18)F-fluorination. Batches of up to 6 GBq [(18)F]altanserin, suitable for human application, with a molar activity of >500 GBq/micromol were obtained within 75 min.
536 _ _ |a Funktion und Dysfunktion des Nervensystems
|c P33
|2 G:(DE-HGF)
|0 G:(DE-Juel1)FUEK409
|x 0
588 _ _ |a Dataset connected to Web of Science, Pubmed
650 _ 2 |2 MeSH
|a Chromatography, High Pressure Liquid
650 _ 2 |2 MeSH
|a Electrochemistry: instrumentation
650 _ 2 |2 MeSH
|a Fluorine Radioisotopes
650 _ 2 |2 MeSH
|a Isotope Labeling: methods
650 _ 2 |2 MeSH
|a Ketanserin: analogs & derivatives
650 _ 2 |2 MeSH
|a Ketanserin: chemistry
650 _ 2 |2 MeSH
|a Ketanserin: isolation & purification
650 _ 7 |0 0
|2 NLM Chemicals
|a Fluorine Radioisotopes
650 _ 7 |0 74050-98-9
|2 NLM Chemicals
|a Ketanserin
650 _ 7 |0 76330-71-7
|2 NLM Chemicals
|a altanserin
650 _ 7 |a J
|2 WoSType
653 2 0 |2 Author
|a electrochemical cell
653 2 0 |2 Author
|a [F-18]altanserin
653 2 0 |2 Author
|a nucleophilic F-18-fluorination
700 1 _ |a Coenen, H. H.
|b 1
|u FZJ
|0 P:(DE-Juel1)131816
773 _ _ |a 10.1016/j.apradiso.2006.03.005
|g Vol. 64, p. 989 - 994
|p 989 - 994
|q 64<989 - 994
|0 PERI:(DE-600)1499873-7
|t Applied radiation and isotopes
|v 64
|y 2006
|x 0969-8043
856 7 _ |u http://dx.doi.org/10.1016/j.apradiso.2006.03.005
909 C O |o oai:juser.fz-juelich.de:54706
|p VDB
913 1 _ |k P33
|v Funktion und Dysfunktion des Nervensystems
|l Funktion und Dysfunktion des Nervensystems
|b Gesundheit
|0 G:(DE-Juel1)FUEK409
|x 0
914 1 _ |y 2006
915 _ _ |0 StatID:(DE-HGF)0010
|a JCR/ISI refereed
920 1 _ |k INC
|l Institut für Nuklearchemie
|d 31.12.2006
|g INC
|0 I:(DE-Juel1)VDB53
|x 0
970 _ _ |a VDB:(DE-Juel1)85557
980 _ _ |a VDB
980 _ _ |a ConvertedRecord
980 _ _ |a journal
980 _ _ |a I:(DE-Juel1)INM-5-20090406
980 _ _ |a UNRESTRICTED
981 _ _ |a I:(DE-Juel1)INM-5-20090406

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