Journal Article

PreJuSER-56804

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Solution Structure and Dynamics of Cartilage Aggrecan

Papagiannopoulos, A. ; Waigh, T. A. ; Hardingham, T. ; Heinrich, M.FZJ*

2006
American Chemical Soc. Columbus, Ohio

This record in other databases:    

Please use a persistent id in citations: doi:10.1021/bm0601373

Abstract: A versatile atom transfer radical polymerization (ATRP) method for polysaccharide grafting in homogeneous mild conditions without using protecting group chemistry is presented. Water/DMF mixtures with different compositions were used as the solvent. The "grafting-from" approach was used in order to prepare suitable pullulan and dextran ATRP macroinitiators with a well controlled degree of functionalization. Methacrylate and acrylamide monomers were grafted obtaining good control over the number, molecular weight and polydispersity of the grafted chains without homopolymer formation and polysaccharide degradation. The versatility of this method allowed us to prepare comblike derivatives with a wide range of properties (amphiphilic, ionic, and thermoresponsive) by simply changing the solvent composition and the catalyst. This could make possible the synthesis of new interesting biomaterials starting from a wide range of polysaccharides.

Keyword(s): Carbohydrate Conformation (MeSH) ; Free Radicals: chemistry (MeSH) ; Hydrolysis (MeSH) ; Kinetics (MeSH) ; Magnetic Resonance Spectroscopy (MeSH) ; Models, Chemical (MeSH) ; Polysaccharides: chemical synthesis (MeSH) ; Polysaccharides: chemistry (MeSH) ; Spectroscopy, Fourier Transform Infrared (MeSH) ; Temperature (MeSH) ; Free Radicals ; Polysaccharides ; J

Note: Record converted from VDB: 12.11.2012

---

Contributing Institute(s):

1. Neutronenstreuung (IFF-NST)

Research Program(s):

1. Kondensierte Materie (P54)
2. Großgeräte für die Forschung mit Photonen, Neutronen und Ionen (PNI) (P55)

Appears in the scientific report 2006
Notes: Nachtrag

---