Journal Article

PreJuSER-5706

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Left cytoarchitectonic area 44 supports selection in the mental lexicon during language production

Heim, S.FZJ* ; Eickhoff, S. B.FZJ* ; Friederici, A. D. ; Amunts, K.FZJ*

2009
Springer Berlin

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Please use a persistent id in citations: doi:10.1007/s00429-009-0213-9

Abstract: This functional magnetic resonance imaging (fMRI) study investigated the role of Broca's region for selecting semantic, syntactic, and phonological information during picture naming. According to psycholinguistic theory, selection is reflected in speech latency differences, e.g. during priming. Here, homogenous (priming) blocks in which German picture names had the same semantic category, syntactic gender, or initial phoneme alternated with heterogeneous (non-priming) blocks. Speech latencies revealed a negative priming effect. Speech latencies were used as regressors for the fMRI data in order to tap selection processes. In Broca's region (BA 44), among others, fMRI data showed repetition priming, which was positive for semantic and syntactic but negative for phonological selection. The different effects in area 44 are discussed in terms of psycholinguistic theory. Overall, the activation pattern is in line with the hypothesis that area 44 generally supports selection processes during noun production at several levels of the mental lexicon.

Keyword(s): Adult (MeSH) ; Analysis of Variance (MeSH) ; Brain Mapping (MeSH) ; Female (MeSH) ; Frontal Lobe: physiology (MeSH) ; Humans (MeSH) ; Image Processing, Computer-Assisted (MeSH) ; Language (MeSH) ; Magnetic Resonance Imaging (MeSH) ; Male (MeSH) ; Photic Stimulation (MeSH) ; Reaction Time (MeSH) ; Semantics (MeSH) ; Verbal Behavior (MeSH) ; J ; Broca's region (auto) ; Area 44 (auto) ; BA 44 (auto) ; Semantic (auto) ; Phonological (auto) ; Syntactic gender (auto) ; fMRI (auto)

Note: This Human Brain Project/ Neuroinformatics research is funded by the National Institute of Biomedical Imaging and Bioengineering, the National Institute of Neurological Disorders and Stroke, and the National Institute of Mental Health (KA). Further support by Helmholtz-Gemeinschaft (VH-N6-012 to KA), the Brain Imaging Center West (BMBF 01GO0204) and the BMBF (01GW0771) is gratefully acknowledged. We thank Barbara Elghahwagi for her assistance with fMRI data recording. Moreover, we appreciate the discussions with Ralph Weidner and Simone Vossel with respect to the fMRI data analysis and the peripheral stimulation devices. We also wish to thank Helen Schreiber for her assistance with the analysis of the behavioural data. Finally, we appreciate the helpful comments by Max Coltheart, Jorg Jescheniak, and four anonymous reviewers on earlier versions of this manuscript.

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Contributing Institute(s):

1. Molekulare Organisation des Gehirns (INM-2)
2. Strukturelle und funktionelle Organisation des Gehirns (INM-1)
3. Jülich-Aachen Research Alliance - Translational Brain Medicine (JARA-BRAIN)

Research Program(s):

1. Funktion und Dysfunktion des Nervensystems (P33)

Appears in the scientific report 2009

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