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000057086 0247_ $$2pmid$$apmid:17012330
000057086 0247_ $$2pmc$$apmc:PMC1779913
000057086 0247_ $$2DOI$$a10.1529/biophysj.105.080382
000057086 0247_ $$2WOS$$aWOS:000242339600032
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000057086 084__ $$2WoS$$aBiophysics
000057086 1001_ $$0P:(DE-Juel1)VDB57655$$aSengupta, K.$$b0$$uFZJ
000057086 245__ $$aSpreading of neutrophils: from activation to migration
000057086 260__ $$aNew York, NY$$bRockefeller Univ. Press$$c2006
000057086 300__ $$a4638 - 4648
000057086 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000057086 440_0 $$0882$$aBiophysical Journal$$v91$$x0006-3495
000057086 500__ $$aRecord converted from VDB: 12.11.2012
000057086 520__ $$aNeutrophils rely on rapid changes in morphology to ward off invaders. Time-resolved dynamics of spreading human neutrophils after activation by the chemoattractant fMLF (formyl methionyl leucyl phenylalanine) was observed by RICM (reflection interference contrast microscopy). An image-processing algorithm was developed to identify the changes in the overall cell shape and the zones of close contact with the substrate. We show that in the case of neutrophils, cell spreading immediately after exposure of fMLF is anisotropic and directional. The dependence of spreading area, A, of the cell as a function of time, t, shows several distinct regimes, each of which can be fitted as power laws (A ~ t(b)). The different spreading regimes correspond to distinct values of the exponent b and are related to the adhesion state of the cell. Treatment with cytochalasin-B eliminated the anisotropy in the spreading.
000057086 536__ $$0G:(DE-Juel1)FUEK414$$2G:(DE-HGF)$$aKondensierte Materie$$cP54$$x0
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000057086 650_2 $$2MeSH$$aActins: metabolism
000057086 650_2 $$2MeSH$$aBicyclo Compounds, Heterocyclic: pharmacology
000057086 650_2 $$2MeSH$$aCell Adhesion
000057086 650_2 $$2MeSH$$aCell Polarity
000057086 650_2 $$2MeSH$$aCell Shape
000057086 650_2 $$2MeSH$$aChemotaxis, Leukocyte
000057086 650_2 $$2MeSH$$aCytochalasin B: pharmacology
000057086 650_2 $$2MeSH$$aHumans
000057086 650_2 $$2MeSH$$aModels, Biological
000057086 650_2 $$2MeSH$$aN-Formylmethionine Leucyl-Phenylalanine: pharmacology
000057086 650_2 $$2MeSH$$aNeutrophil Activation
000057086 650_2 $$2MeSH$$aNeutrophils: physiology
000057086 650_2 $$2MeSH$$aThiazolidines: pharmacology
000057086 650_7 $$00$$2NLM Chemicals$$aActins
000057086 650_7 $$00$$2NLM Chemicals$$aBicyclo Compounds, Heterocyclic
000057086 650_7 $$00$$2NLM Chemicals$$aThiazolidines
000057086 650_7 $$014930-96-2$$2NLM Chemicals$$aCytochalasin B
000057086 650_7 $$059880-97-6$$2NLM Chemicals$$aN-Formylmethionine Leucyl-Phenylalanine
000057086 650_7 $$076343-93-6$$2NLM Chemicals$$alatrunculin A
000057086 650_7 $$2WoSType$$aJ
000057086 7001_ $$0P:(DE-HGF)0$$aAranda-Espinoza, H.$$b1
000057086 7001_ $$0P:(DE-HGF)0$$aSmith, L.$$b2
000057086 7001_ $$0P:(DE-HGF)0$$aJanmey, P.$$b3
000057086 7001_ $$0P:(DE-HGF)0$$aHammer, D.$$b4
000057086 773__ $$0PERI:(DE-600)1477214-0$$a10.1529/biophysj.105.080382$$gVol. 91, p. 4638 - 4648$$p4638 - 4648$$q91<4638 - 4648$$tBiophysical journal$$v91$$x0006-3495$$y2006
000057086 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779913
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000057086 9141_ $$aNachtrag$$y2006
000057086 915__ $$0StatID:(DE-HGF)0010$$aJCR/ISI refereed
000057086 9201_ $$0I:(DE-Juel1)VDB421$$d31.12.2006$$gISG$$kISG-4$$lBiologische Schichten$$x1
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