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@ARTICLE{Sengupta:57086,
      author       = {Sengupta, K. and Aranda-Espinoza, H. and Smith, L. and
                      Janmey, P. and Hammer, D.},
      title        = {{S}preading of neutrophils: from activation to migration},
      journal      = {Biophysical journal},
      volume       = {91},
      issn         = {0006-3495},
      address      = {New York, NY},
      publisher    = {Rockefeller Univ. Press},
      reportid     = {PreJuSER-57086},
      pages        = {4638 - 4648},
      year         = {2006},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {Neutrophils rely on rapid changes in morphology to ward off
                      invaders. Time-resolved dynamics of spreading human
                      neutrophils after activation by the chemoattractant fMLF
                      (formyl methionyl leucyl phenylalanine) was observed by RICM
                      (reflection interference contrast microscopy). An
                      image-processing algorithm was developed to identify the
                      changes in the overall cell shape and the zones of close
                      contact with the substrate. We show that in the case of
                      neutrophils, cell spreading immediately after exposure of
                      fMLF is anisotropic and directional. The dependence of
                      spreading area, A, of the cell as a function of time, t,
                      shows several distinct regimes, each of which can be fitted
                      as power laws (A ~ t(b)). The different spreading regimes
                      correspond to distinct values of the exponent b and are
                      related to the adhesion state of the cell. Treatment with
                      cytochalasin-B eliminated the anisotropy in the spreading.},
      keywords     = {Actins: metabolism / Bicyclo Compounds, Heterocyclic:
                      pharmacology / Cell Adhesion / Cell Polarity / Cell Shape /
                      Chemotaxis, Leukocyte / Cytochalasin B: pharmacology /
                      Humans / Models, Biological / N-Formylmethionine
                      Leucyl-Phenylalanine: pharmacology / Neutrophil Activation /
                      Neutrophils: physiology / Thiazolidines: pharmacology /
                      Actins (NLM Chemicals) / Bicyclo Compounds, Heterocyclic
                      (NLM Chemicals) / Thiazolidines (NLM Chemicals) /
                      Cytochalasin B (NLM Chemicals) / N-Formylmethionine
                      Leucyl-Phenylalanine (NLM Chemicals) / latrunculin A (NLM
                      Chemicals) / J (WoSType)},
      cin          = {ISG-4},
      ddc          = {570},
      cid          = {I:(DE-Juel1)VDB421},
      pnm          = {Kondensierte Materie},
      pid          = {G:(DE-Juel1)FUEK414},
      shelfmark    = {Biophysics},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:17012330},
      pmc          = {pmc:PMC1779913},
      UT           = {WOS:000242339600032},
      doi          = {10.1529/biophysj.105.080382},
      url          = {https://juser.fz-juelich.de/record/57086},
}