Hauptseite > Publikationsdatenbank > Spreading of neutrophils: from activation to migration > print

001     57086
005     20200402210343.0
024 7 _ |2 pmid
|a pmid:17012330
024 7 _ |2 pmc
|a pmc:PMC1779913
024 7 _ |2 DOI
|a 10.1529/biophysj.105.080382
024 7 _ |2 WOS
|a WOS:000242339600032
037 _ _ |a PreJuSER-57086
041 _ _ |a eng
082 _ _ |a 570
084 _ _ |2 WoS
|a Biophysics
100 1 _ |a Sengupta, K.
|b 0
|u FZJ
|0 P:(DE-Juel1)VDB57655
245 _ _ |a Spreading of neutrophils: from activation to migration
260 _ _ |a New York, NY
|b Rockefeller Univ. Press
|c 2006
300 _ _ |a 4638 - 4648
336 7 _ |a Journal Article
|0 PUB:(DE-HGF)16
|2 PUB:(DE-HGF)
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|0 0
|2 EndNote
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a article
|2 DRIVER
440 _ 0 |a Biophysical Journal
|x 0006-3495
|0 882
|v 91
500 _ _ |a Record converted from VDB: 12.11.2012
520 _ _ |a Neutrophils rely on rapid changes in morphology to ward off invaders. Time-resolved dynamics of spreading human neutrophils after activation by the chemoattractant fMLF (formyl methionyl leucyl phenylalanine) was observed by RICM (reflection interference contrast microscopy). An image-processing algorithm was developed to identify the changes in the overall cell shape and the zones of close contact with the substrate. We show that in the case of neutrophils, cell spreading immediately after exposure of fMLF is anisotropic and directional. The dependence of spreading area, A, of the cell as a function of time, t, shows several distinct regimes, each of which can be fitted as power laws (A ~ t(b)). The different spreading regimes correspond to distinct values of the exponent b and are related to the adhesion state of the cell. Treatment with cytochalasin-B eliminated the anisotropy in the spreading.
536 _ _ |a Kondensierte Materie
|c P54
|2 G:(DE-HGF)
|0 G:(DE-Juel1)FUEK414
|x 0
588 _ _ |a Dataset connected to Web of Science, Pubmed
650 _ 2 |2 MeSH
|a Actins: metabolism
650 _ 2 |2 MeSH
|a Bicyclo Compounds, Heterocyclic: pharmacology
650 _ 2 |2 MeSH
|a Cell Adhesion
650 _ 2 |2 MeSH
|a Cell Polarity
650 _ 2 |2 MeSH
|a Cell Shape
650 _ 2 |2 MeSH
|a Chemotaxis, Leukocyte
650 _ 2 |2 MeSH
|a Cytochalasin B: pharmacology
650 _ 2 |2 MeSH
|a Humans
650 _ 2 |2 MeSH
|a Models, Biological
650 _ 2 |2 MeSH
|a N-Formylmethionine Leucyl-Phenylalanine: pharmacology
650 _ 2 |2 MeSH
|a Neutrophil Activation
650 _ 2 |2 MeSH
|a Neutrophils: physiology
650 _ 2 |2 MeSH
|a Thiazolidines: pharmacology
650 _ 7 |0 0
|2 NLM Chemicals
|a Actins
650 _ 7 |0 0
|2 NLM Chemicals
|a Bicyclo Compounds, Heterocyclic
650 _ 7 |0 0
|2 NLM Chemicals
|a Thiazolidines
650 _ 7 |0 14930-96-2
|2 NLM Chemicals
|a Cytochalasin B
650 _ 7 |0 59880-97-6
|2 NLM Chemicals
|a N-Formylmethionine Leucyl-Phenylalanine
650 _ 7 |0 76343-93-6
|2 NLM Chemicals
|a latrunculin A
650 _ 7 |a J
|2 WoSType
700 1 _ |a Aranda-Espinoza, H.
|b 1
|0 P:(DE-HGF)0
700 1 _ |a Smith, L.
|b 2
|0 P:(DE-HGF)0
700 1 _ |a Janmey, P.
|b 3
|0 P:(DE-HGF)0
700 1 _ |a Hammer, D.
|b 4
|0 P:(DE-HGF)0
773 _ _ |a 10.1529/biophysj.105.080382
|g Vol. 91, p. 4638 - 4648
|p 4638 - 4648
|q 91<4638 - 4648
|0 PERI:(DE-600)1477214-0
|t Biophysical journal
|v 91
|y 2006
|x 0006-3495
856 7 _ |2 Pubmed Central
|u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779913
909 C O |o oai:juser.fz-juelich.de:57086
|p VDB
913 1 _ |k P54
|v Kondensierte Materie
|l Kondensierte Materie
|b Materie
|z entfällt bis 2009
|0 G:(DE-Juel1)FUEK414
|x 0
914 1 _ |a Nachtrag
|y 2006
915 _ _ |0 StatID:(DE-HGF)0010
|a JCR/ISI refereed
920 1 _ |k ISG-4
|l Biologische Schichten
|d 31.12.2006
|g ISG
|0 I:(DE-Juel1)VDB421
|x 1
970 _ _ |a VDB:(DE-Juel1)89804
980 _ _ |a VDB
980 _ _ |a ConvertedRecord
980 _ _ |a journal
980 _ _ |a I:(DE-Juel1)ICS-7-20110106
980 _ _ |a UNRESTRICTED
981 _ _ |a I:(DE-Juel1)IBI-2-20200312
981 _ _ |a I:(DE-Juel1)ICS-7-20110106

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21