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000057202 0247_ $$2DOI$$a10.1016/j.bios.2006.04.001
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000057202 084__ $$2WoS$$aBiophysics
000057202 084__ $$2WoS$$aBiotechnology & Applied Microbiology
000057202 084__ $$2WoS$$aChemistry, Analytical
000057202 084__ $$2WoS$$aElectrochemistry
000057202 084__ $$2WoS$$aNanoscience & Nanotechnology
000057202 1001_ $$0P:(DE-HGF)0$$aMeyer, M. H. F.$$b0
000057202 245__ $$aCRP determination based on a novel magnetic biosensor
000057202 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2007
000057202 300__ $$a973 - 979
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000057202 440_0 $$v22
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000057202 520__ $$aThe c-reactive protein (CRP) is a very significant human blood marker for inflammatory processes and is routinely determined for many clinical purposes. The widespread and well established detection method for this approximately 115 kDa hepatic protein is the high-sensitivity ELISA assay (hsCRP-ELISA) in blood serum. New approaches in medical CRP diagnosis (e.g. for CVD, inflammatory bowel disease) require rapid quantification in native matrices. A novel CRP determination method based on magnetic detection is described and tested for human blood serum, saliva and urine. The detection principle is based on two different anti-CRP antibodies (monoclonal, IgG) for CRP trapment and labelling. The linear detection range of this immunosensor ranged from 25 ng/ml to 2.5 microg/ml and is therefore much more sensitive than typical hsCRP-ELISA-assays.
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000057202 650_2 $$2MeSH$$aBiological Markers: blood
000057202 650_2 $$2MeSH$$aBiosensing Techniques: instrumentation
000057202 650_2 $$2MeSH$$aBiosensing Techniques: methods
000057202 650_2 $$2MeSH$$aBlood Chemical Analysis: instrumentation
000057202 650_2 $$2MeSH$$aBlood Chemical Analysis: methods
000057202 650_2 $$2MeSH$$aC-Reactive Protein: analysis
000057202 650_2 $$2MeSH$$aEquipment Design
000057202 650_2 $$2MeSH$$aEquipment Failure Analysis
000057202 650_2 $$2MeSH$$aHumans
000057202 650_2 $$2MeSH$$aImmunoassay: instrumentation
000057202 650_2 $$2MeSH$$aImmunoassay: methods
000057202 650_2 $$2MeSH$$aImmunomagnetic Separation: instrumentation
000057202 650_2 $$2MeSH$$aImmunomagnetic Separation: methods
000057202 650_2 $$2MeSH$$aInflammation: blood
000057202 650_2 $$2MeSH$$aInflammation: diagnosis
000057202 650_2 $$2MeSH$$aMagnetics: diagnostic use
000057202 650_2 $$2MeSH$$aMagnetics: instrumentation
000057202 650_2 $$2MeSH$$aMicrochemistry: instrumentation
000057202 650_2 $$2MeSH$$aMicrochemistry: methods
000057202 650_2 $$2MeSH$$aSensitivity and Specificity
000057202 650_7 $$00$$2NLM Chemicals$$aBiological Markers
000057202 650_7 $$09007-41-4$$2NLM Chemicals$$aC-Reactive Protein
000057202 650_7 $$2WoSType$$aJ
000057202 65320 $$2Author$$ac-reactive protein (CRP)
000057202 65320 $$2Author$$amagnetic detection
000057202 65320 $$2Author$$aimmumosensor
000057202 65320 $$2Author$$ainflammation
000057202 65320 $$2Author$$aCVD
000057202 65320 $$2Author$$aIBD
000057202 7001_ $$0P:(DE-HGF)0$$aHartmann, M.$$b1
000057202 7001_ $$0P:(DE-Juel1)128697$$aKrause, H.-J.$$b2$$uFZJ
000057202 7001_ $$0P:(DE-HGF)0$$aBlankenstein, G.$$b3
000057202 7001_ $$0P:(DE-HGF)0$$aMüller-Chorus, B.$$b4
000057202 7001_ $$0P:(DE-HGF)0$$aOster, J.$$b5
000057202 7001_ $$0P:(DE-HGF)0$$aMiethe, P.$$b6
000057202 7001_ $$0P:(DE-Juel1)VDB15243$$aKeusgen, M.$$b7$$uFZJ
000057202 773__ $$0PERI:(DE-600)1496379-6$$a10.1016/j.bios.2006.04.001$$gVol. 22, p. 973 - 979$$p973 - 979$$q22<973 - 979$$tBiosensors and bioelectronics$$v22$$x0956-5663$$y2007
000057202 8567_ $$uhttp://dx.doi.org/10.1016/j.bios.2006.04.001
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000057202 915__ $$0StatID:(DE-HGF)0010$$aJCR/ISI refereed
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