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@ARTICLE{Meyer:57202,
      author       = {Meyer, M. H. F. and Hartmann, M. and Krause, H.-J. and
                      Blankenstein, G. and Müller-Chorus, B. and Oster, J. and
                      Miethe, P. and Keusgen, M.},
      title        = {{CRP} determination based on a novel magnetic biosensor},
      journal      = {Biosensors and bioelectronics},
      volume       = {22},
      issn         = {0956-5663},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {PreJuSER-57202},
      pages        = {973 - 979},
      year         = {2007},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {The c-reactive protein (CRP) is a very significant human
                      blood marker for inflammatory processes and is routinely
                      determined for many clinical purposes. The widespread and
                      well established detection method for this approximately 115
                      kDa hepatic protein is the high-sensitivity ELISA assay
                      (hsCRP-ELISA) in blood serum. New approaches in medical CRP
                      diagnosis (e.g. for CVD, inflammatory bowel disease) require
                      rapid quantification in native matrices. A novel CRP
                      determination method based on magnetic detection is
                      described and tested for human blood serum, saliva and
                      urine. The detection principle is based on two different
                      anti-CRP antibodies (monoclonal, IgG) for CRP trapment and
                      labelling. The linear detection range of this immunosensor
                      ranged from 25 ng/ml to 2.5 microg/ml and is therefore much
                      more sensitive than typical hsCRP-ELISA-assays.},
      keywords     = {Biological Markers: blood / Biosensing Techniques:
                      instrumentation / Biosensing Techniques: methods / Blood
                      Chemical Analysis: instrumentation / Blood Chemical
                      Analysis: methods / C-Reactive Protein: analysis / Equipment
                      Design / Equipment Failure Analysis / Humans / Immunoassay:
                      instrumentation / Immunoassay: methods / Immunomagnetic
                      Separation: instrumentation / Immunomagnetic Separation:
                      methods / Inflammation: blood / Inflammation: diagnosis /
                      Magnetics: diagnostic use / Magnetics: instrumentation /
                      Microchemistry: instrumentation / Microchemistry: methods /
                      Sensitivity and Specificity / Biological Markers (NLM
                      Chemicals) / C-Reactive Protein (NLM Chemicals) / J
                      (WoSType)},
      cin          = {CNI / IBN-2},
      ddc          = {570},
      cid          = {I:(DE-Juel1)VDB381 / I:(DE-Juel1)IBN-2-20090406},
      pnm          = {Grundlagen für zukünftige Informationstechnologien},
      pid          = {G:(DE-Juel1)FUEK412},
      shelfmark    = {Biophysics / Biotechnology $\&$ Applied Microbiology /
                      Chemistry, Analytical / Electrochemistry / Nanoscience $\&$
                      Nanotechnology},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:16766177},
      UT           = {WOS:000243541800027},
      doi          = {10.1016/j.bios.2006.04.001},
      url          = {https://juser.fz-juelich.de/record/57202},
}