001     57202
005     20190625110850.0
024 7 _ |2 pmid
|a pmid:16766177
024 7 _ |2 DOI
|a 10.1016/j.bios.2006.04.001
024 7 _ |2 WOS
|a WOS:000243541800027
024 7 _ |a altmetric:21817236
|2 altmetric
037 _ _ |a PreJuSER-57202
041 _ _ |a eng
082 _ _ |a 570
084 _ _ |2 WoS
|a Biophysics
084 _ _ |2 WoS
|a Biotechnology & Applied Microbiology
084 _ _ |2 WoS
|a Chemistry, Analytical
084 _ _ |2 WoS
|a Electrochemistry
084 _ _ |2 WoS
|a Nanoscience & Nanotechnology
100 1 _ |a Meyer, M. H. F.
|b 0
|0 P:(DE-HGF)0
245 _ _ |a CRP determination based on a novel magnetic biosensor
260 _ _ |a Amsterdam [u.a.]
|b Elsevier Science
|c 2007
300 _ _ |a 973 - 979
336 7 _ |a Journal Article
|0 PUB:(DE-HGF)16
|2 PUB:(DE-HGF)
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|0 0
|2 EndNote
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a article
|2 DRIVER
440 _ 0 |v 22
500 _ _ |a Record converted from VDB: 12.11.2012
520 _ _ |a The c-reactive protein (CRP) is a very significant human blood marker for inflammatory processes and is routinely determined for many clinical purposes. The widespread and well established detection method for this approximately 115 kDa hepatic protein is the high-sensitivity ELISA assay (hsCRP-ELISA) in blood serum. New approaches in medical CRP diagnosis (e.g. for CVD, inflammatory bowel disease) require rapid quantification in native matrices. A novel CRP determination method based on magnetic detection is described and tested for human blood serum, saliva and urine. The detection principle is based on two different anti-CRP antibodies (monoclonal, IgG) for CRP trapment and labelling. The linear detection range of this immunosensor ranged from 25 ng/ml to 2.5 microg/ml and is therefore much more sensitive than typical hsCRP-ELISA-assays.
536 _ _ |a Grundlagen für zukünftige Informationstechnologien
|c P42
|2 G:(DE-HGF)
|0 G:(DE-Juel1)FUEK412
|x 0
588 _ _ |a Dataset connected to Web of Science, Pubmed
650 _ 2 |2 MeSH
|a Biological Markers: blood
650 _ 2 |2 MeSH
|a Biosensing Techniques: instrumentation
650 _ 2 |2 MeSH
|a Biosensing Techniques: methods
650 _ 2 |2 MeSH
|a Blood Chemical Analysis: instrumentation
650 _ 2 |2 MeSH
|a Blood Chemical Analysis: methods
650 _ 2 |2 MeSH
|a C-Reactive Protein: analysis
650 _ 2 |2 MeSH
|a Equipment Design
650 _ 2 |2 MeSH
|a Equipment Failure Analysis
650 _ 2 |2 MeSH
|a Humans
650 _ 2 |2 MeSH
|a Immunoassay: instrumentation
650 _ 2 |2 MeSH
|a Immunoassay: methods
650 _ 2 |2 MeSH
|a Immunomagnetic Separation: instrumentation
650 _ 2 |2 MeSH
|a Immunomagnetic Separation: methods
650 _ 2 |2 MeSH
|a Inflammation: blood
650 _ 2 |2 MeSH
|a Inflammation: diagnosis
650 _ 2 |2 MeSH
|a Magnetics: diagnostic use
650 _ 2 |2 MeSH
|a Magnetics: instrumentation
650 _ 2 |2 MeSH
|a Microchemistry: instrumentation
650 _ 2 |2 MeSH
|a Microchemistry: methods
650 _ 2 |2 MeSH
|a Sensitivity and Specificity
650 _ 7 |0 0
|2 NLM Chemicals
|a Biological Markers
650 _ 7 |0 9007-41-4
|2 NLM Chemicals
|a C-Reactive Protein
650 _ 7 |a J
|2 WoSType
653 2 0 |2 Author
|a c-reactive protein (CRP)
653 2 0 |2 Author
|a magnetic detection
653 2 0 |2 Author
|a immumosensor
653 2 0 |2 Author
|a inflammation
653 2 0 |2 Author
|a CVD
653 2 0 |2 Author
|a IBD
700 1 _ |a Hartmann, M.
|b 1
|0 P:(DE-HGF)0
700 1 _ |a Krause, H.-J.
|b 2
|u FZJ
|0 P:(DE-Juel1)128697
700 1 _ |a Blankenstein, G.
|b 3
|0 P:(DE-HGF)0
700 1 _ |a Müller-Chorus, B.
|b 4
|0 P:(DE-HGF)0
700 1 _ |a Oster, J.
|b 5
|0 P:(DE-HGF)0
700 1 _ |a Miethe, P.
|b 6
|0 P:(DE-HGF)0
700 1 _ |a Keusgen, M.
|b 7
|u FZJ
|0 P:(DE-Juel1)VDB15243
773 _ _ |a 10.1016/j.bios.2006.04.001
|g Vol. 22, p. 973 - 979
|p 973 - 979
|q 22<973 - 979
|0 PERI:(DE-600)1496379-6
|t Biosensors and bioelectronics
|v 22
|y 2007
|x 0956-5663
856 7 _ |u http://dx.doi.org/10.1016/j.bios.2006.04.001
909 C O |o oai:juser.fz-juelich.de:57202
|p VDB
913 1 _ |k P42
|v Grundlagen für zukünftige Informationstechnologien
|l Grundlagen für zukünftige Informationstechnologien (FIT)
|b Schlüsseltechnologien
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|x 0
914 1 _ |y 2007
915 _ _ |0 StatID:(DE-HGF)0010
|a JCR/ISI refereed
920 1 _ |k CNI
|l Center of Nanoelectronic Systems for Information Technology
|d 14.09.2008
|g CNI
|z 381
|0 I:(DE-Juel1)VDB381
|x 1
920 1 _ |k IBN-2
|l Bioelektronik
|d 31.12.2010
|g IBN
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|x 0
970 _ _ |a VDB:(DE-Juel1)89978
980 _ _ |a VDB
980 _ _ |a ConvertedRecord
980 _ _ |a journal
980 _ _ |a I:(DE-Juel1)VDB381
980 _ _ |a I:(DE-Juel1)IBN-2-20090406
980 _ _ |a UNRESTRICTED
981 _ _ |a I:(DE-Juel1)IBN-2-20090406


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