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| 001 | 57477 | ||
| 005 | 20200402205930.0 | ||
| 024 | 7 | _ | |2 pmid |a pmid:17668006 |
| 024 | 7 | _ | |2 pmc |a pmc:PMC1978089 |
| 024 | 7 | _ | |2 DOI |a 10.1038/sj.embor.7401025 |
| 024 | 7 | _ | |2 WOS |a WOS:000248447300011 |
| 037 | _ | _ | |a PreJuSER-57477 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 570 |
| 084 | _ | _ | |2 WoS |a Biochemistry & Molecular Biology |
| 084 | _ | _ | |2 WoS |a Cell Biology |
| 100 | 1 | _ | |a Cukkemane, A. |b 0 |u FZJ |0 P:(DE-Juel1)VDB69395 |
| 245 | _ | _ | |a Subunits act independently in a cyclic nucleotide-activated K+ channel |
| 260 | _ | _ | |a London [u.a.] |b Nature Publishing Group |c 2007 |
| 300 | _ | _ | |a 749 - 755 |
| 336 | 7 | _ | |a Journal Article |0 PUB:(DE-HGF)16 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a article |2 DRIVER |
| 440 | _ | 0 | |a EMBO Reports |x 1469-221X |0 12322 |y 8 |v 8 |
| 500 | _ | _ | |a Record converted from VDB: 12.11.2012 |
| 520 | _ | _ | |a Ion channels gated by cyclic nucleotides have crucial roles in neuronal excitability and signal transduction of sensory neurons. Here, we studied ligand binding of a cyclic nucleotide-activated K(+) channel from Mesorhizobium loti and its isolated cyclic nucleotide-binding domain. The channel and the binding domain alone bind cyclic AMP with similar affinity in a non-cooperative manner. The cAMP sensitivities of binding and activation coincide. Thus, each subunit in the tetrameric channel acts independently of the others. The binding and gating properties of the bacterial channel are distinctively different from those of eukaryotic cyclic nucleotide-gated channels. |
| 536 | _ | _ | |a Funktion und Dysfunktion des Nervensystems |c P33 |2 G:(DE-HGF) |0 G:(DE-Juel1)FUEK409 |x 0 |
| 588 | _ | _ | |a Dataset connected to Web of Science, Pubmed |
| 650 | _ | 2 | |2 MeSH |a Alphaproteobacteria: metabolism |
| 650 | _ | 2 | |2 MeSH |a Bacterial Proteins: chemistry |
| 650 | _ | 2 | |2 MeSH |a Bacterial Proteins: genetics |
| 650 | _ | 2 | |2 MeSH |a Cyclic AMP: chemistry |
| 650 | _ | 2 | |2 MeSH |a Cyclic Nucleotide-Gated Cation Channels: chemistry |
| 650 | _ | 2 | |2 MeSH |a Cyclic Nucleotide-Gated Cation Channels: genetics |
| 650 | _ | 2 | |2 MeSH |a Ligands |
| 650 | _ | 2 | |2 MeSH |a Potassium Channels: chemistry |
| 650 | _ | 2 | |2 MeSH |a Potassium Channels: genetics |
| 650 | _ | 2 | |2 MeSH |a Protein Structure, Tertiary |
| 650 | _ | 2 | |2 MeSH |a Protein Subunits: chemistry |
| 650 | _ | 2 | |2 MeSH |a Spectrometry, Fluorescence |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Bacterial Proteins |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Cyclic Nucleotide-Gated Cation Channels |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Ligands |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Potassium Channels |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Protein Subunits |
| 650 | _ | 7 | |0 60-92-4 |2 NLM Chemicals |a Cyclic AMP |
| 650 | _ | 7 | |a J |2 WoSType |
| 653 | 2 | 0 | |2 Author |a cyclic nucleotides |
| 653 | 2 | 0 | |2 Author |a fluorescence assay |
| 653 | 2 | 0 | |2 Author |a ion channels |
| 653 | 2 | 0 | |2 Author |a ITC |
| 653 | 2 | 0 | |2 Author |a signalling |
| 700 | 1 | _ | |a Grüter, B. |b 1 |u FZJ |0 P:(DE-Juel1)VDB64412 |
| 700 | 1 | _ | |a Novak, K. |b 2 |u FZJ |0 P:(DE-Juel1)VDB15802 |
| 700 | 1 | _ | |a Gensch, T. |b 3 |u FZJ |0 P:(DE-Juel1)131924 |
| 700 | 1 | _ | |a Bönigk, W. |b 4 |u FZJ |0 P:(DE-Juel1)VDB22199 |
| 700 | 1 | _ | |a Gerharz, T. |b 5 |u FZJ |0 P:(DE-Juel1)VDB2886 |
| 700 | 1 | _ | |a Kaupp, U. B. |b 6 |u FZJ |0 P:(DE-Juel1)VDB728 |
| 700 | 1 | _ | |a Seifert, R. |b 7 |u FZJ |0 P:(DE-Juel1)VDB1505 |
| 773 | _ | _ | |a 10.1038/sj.embor.7401025 |g Vol. 8, p. 749 - 755 |p 749 - 755 |q 8<749 - 755 |0 PERI:(DE-600)2025376-X |t EMBO reports |v 8 |y 2007 |x 1469-221X |
| 856 | 7 | _ | |2 Pubmed Central |u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978089 |
| 909 | C | O | |o oai:juser.fz-juelich.de:57477 |p VDB |
| 913 | 1 | _ | |k P33 |v Funktion und Dysfunktion des Nervensystems |l Funktion und Dysfunktion des Nervensystems |b Gesundheit |0 G:(DE-Juel1)FUEK409 |x 0 |
| 914 | 1 | _ | |y 2007 |
| 915 | _ | _ | |0 StatID:(DE-HGF)0010 |a JCR/ISI refereed |
| 920 | 1 | _ | |k IBT-1 |l Biotechnologie 1 |g IBT |z ab 31.10.10 weitergeführt als IBG-1 |0 I:(DE-Juel1)VDB55 |x 1 |
| 920 | 1 | _ | |k INB-1 |l Zelluläre Biophysik |d 31.12.2008 |g INB |0 I:(DE-Juel1)VDB804 |x 0 |
| 970 | _ | _ | |a VDB:(DE-Juel1)90421 |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a ConvertedRecord |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a I:(DE-Juel1)IBG-1-20101118 |
| 980 | _ | _ | |a I:(DE-Juel1)ICS-4-20110106 |
| 980 | _ | _ | |a UNRESTRICTED |
| 981 | _ | _ | |a I:(DE-Juel1)IBI-1-20200312 |
| 981 | _ | _ | |a I:(DE-Juel1)IBG-1-20101118 |
| 981 | _ | _ | |a I:(DE-Juel1)ICS-4-20110106 |
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