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| Journal Article | PreJuSER-57477 |
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2007
Nature Publishing Group
London [u.a.]
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Please use a persistent id in citations: doi:10.1038/sj.embor.7401025
Abstract: Ion channels gated by cyclic nucleotides have crucial roles in neuronal excitability and signal transduction of sensory neurons. Here, we studied ligand binding of a cyclic nucleotide-activated K(+) channel from Mesorhizobium loti and its isolated cyclic nucleotide-binding domain. The channel and the binding domain alone bind cyclic AMP with similar affinity in a non-cooperative manner. The cAMP sensitivities of binding and activation coincide. Thus, each subunit in the tetrameric channel acts independently of the others. The binding and gating properties of the bacterial channel are distinctively different from those of eukaryotic cyclic nucleotide-gated channels.
Keyword(s): Alphaproteobacteria: metabolism (MeSH) ; Bacterial Proteins: chemistry (MeSH) ; Bacterial Proteins: genetics (MeSH) ; Cyclic AMP: chemistry (MeSH) ; Cyclic Nucleotide-Gated Cation Channels: chemistry (MeSH) ; Cyclic Nucleotide-Gated Cation Channels: genetics (MeSH) ; Ligands (MeSH) ; Potassium Channels: chemistry (MeSH) ; Potassium Channels: genetics (MeSH) ; Protein Structure, Tertiary (MeSH) ; Protein Subunits: chemistry (MeSH) ; Spectrometry, Fluorescence (MeSH) ; Bacterial Proteins ; Cyclic Nucleotide-Gated Cation Channels ; Ligands ; Potassium Channels ; Protein Subunits ; Cyclic AMP ; J ; cyclic nucleotides (auto) ; fluorescence assay (auto) ; ion channels (auto) ; ITC (auto) ; signalling (auto)
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