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@ARTICLE{Ingebrandt:58310,
      author       = {Ingebrandt, S. and Han, Y. and Nakamura, F. and Poghossian,
                      A. and Schöning, M. J. and Offenhäusser, A.},
      title        = {{L}abel-free detection of single nucleotide polymorphisms
                      utilizing the differential transfer function},
      journal      = {Biosensors and bioelectronics},
      volume       = {22},
      issn         = {0956-5663},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {PreJuSER-58310},
      pages        = {2834 - 2840},
      year         = {2007},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {We present a label-free method for the detection of DNA
                      hybridization, which is monitored by non-metallized silicon
                      field-effect transistors (FET) in a microarray approach. The
                      described method enables a fast and fully electronic readout
                      of ex situ binding assays. The label-free detection
                      utilizing the field-effect is based on the intrinsic charge
                      of the DNA molecules and/or on changes of the solid-liquid
                      interface impedance, when biomolecules bind to the sensor
                      surface. With our sensor system, usually a time-resolved, dc
                      readout is used. In general, this FET signal suffers from
                      sensor drift, temperature drift, changes in electrolyte
                      composition or pH value, influence of the reference
                      electrode, etc. In this article, we present a differential
                      ac readout concept for FET microarrays, which enables a
                      stable operation of the sensor against many of these
                      side-parameters, reliable readout and a possibility for a
                      quick screening of large sensor arrays. We present the
                      detection of point mutations in short DNA samples with this
                      method in an ex situ binding assay.},
      keywords     = {Biosensing Techniques: instrumentation / Biosensing
                      Techniques: methods / DNA: analysis / DNA: genetics /
                      Nucleic Acid Hybridization / Polymorphism, Single Nucleotide
                      / Potentiometry / Transistors, Electronic / DNA (NLM
                      Chemicals) / J (WoSType)},
      cin          = {CNI / IBN-2 / JARA-FIT},
      ddc          = {570},
      cid          = {I:(DE-Juel1)VDB381 / I:(DE-Juel1)IBN-2-20090406 /
                      $I:(DE-82)080009_20140620$},
      pnm          = {Grundlagen für zukünftige Informationstechnologien},
      pid          = {G:(DE-Juel1)FUEK412},
      shelfmark    = {Biophysics / Biotechnology $\&$ Applied Microbiology /
                      Chemistry, Analytical / Electrochemistry / Nanoscience $\&$
                      Nanotechnology},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:17187976},
      UT           = {WOS:000247555300010},
      doi          = {10.1016/j.bios.2006.11.019},
      url          = {https://juser.fz-juelich.de/record/58310},
}