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000005895 0247_ $$2pmid$$apmid:19777513
000005895 0247_ $$2DOI$$a10.1002/chem.200901046
000005895 0247_ $$2WOS$$aWOS:000271992100033
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000005895 041__ $$aeng
000005895 082__ $$a540
000005895 084__ $$2WoS$$aChemistry, Multidisciplinary
000005895 1001_ $$0P:(DE-Juel1)VDB39656$$aKohlmann, C.$$b0$$uFZJ
000005895 245__ $$aIonic Liquides as Performance Additives for Electroenzymatic Syntheses
000005895 260__ $$aWeinheim$$bWiley-VCH$$c2009
000005895 300__ $$a11692 - 11700
000005895 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000005895 3367_ $$2DRIVER$$aarticle
000005895 440_0 $$01226$$aChemistry-a European Journal$$v15$$x0947-6539$$y43
000005895 500__ $$aThe authors thank Lilia Harter, Stephanie Corsten and Zubeyda Dogan for excellent work in the lab and the GK 1166 "BioNoCo" for fruitful discussion and funding. L.G. thanks the cluster of excellence "Tailor-Made Fuels from Biomass" (TMFB) for support.
000005895 520__ $$aElectroenzymatic syntheses combine oxidoreductase-catalysed reactions with electrochemical reactant supply. The use of ionic liquids as performance additives can contribute to overcoming existing limitations of these syntheses. Here, we report on the influence of different water-miscible ionic liquids on critical parameters such as conductivity, biocatalyst activity and stability or substrate solubility for three typical electroenzymatic syntheses. In these investigations promising ionic liquids were identified and have been used as additives for batch electrolyses on preparative scale for the three electroenzymatic systems. It was possible to improve the space-time-yield for the electrochemical regeneration of NADPH by a factor of three. For an amino acid oxidase catalysed resolution of a methionine racemate with ferrocene-mediated electrochemical regeneration of the enzyme-bound cofactor FAD a 50% increase in space time yield and 140% increase in catalyst utilisation (TTN) were achieved. Furthermore, for the chloroperoxidase-catalysed synthesis of (R)-phenylmethylsulfoxide with electrochemical generation of the required cosubstrate H2O2 the space time yield and the catalyst utilisation were improved by a factor of up to 4.2 depending on the ionic liquids used.
000005895 536__ $$0G:(DE-Juel1)FUEK410$$2G:(DE-HGF)$$aBiotechnologie$$cPBT$$x0
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000005895 65320 $$2Author$$abiocatalysis
000005895 65320 $$2Author$$abiotechnology
000005895 65320 $$2Author$$aelectroenzymatic synthesis
000005895 65320 $$2Author$$aionic liquids
000005895 65320 $$2Author$$asustainable chemistry
000005895 650_2 $$2MeSH$$aAmino Acid Oxidoreductases: metabolism
000005895 650_2 $$2MeSH$$aBiocatalysis
000005895 650_2 $$2MeSH$$aChloride Peroxidase: metabolism
000005895 650_2 $$2MeSH$$aElectrochemical Techniques
000005895 650_2 $$2MeSH$$aFlavin-Adenine Dinucleotide: metabolism
000005895 650_2 $$2MeSH$$aHydrogen Peroxide: metabolism
000005895 650_2 $$2MeSH$$aIonic Liquids: chemistry
000005895 650_2 $$2MeSH$$aNADP: metabolism
000005895 650_2 $$2MeSH$$aSolubility
000005895 650_7 $$00$$2NLM Chemicals$$aIonic Liquids
000005895 650_7 $$0146-14-5$$2NLM Chemicals$$aFlavin-Adenine Dinucleotide
000005895 650_7 $$053-59-8$$2NLM Chemicals$$aNADP
000005895 650_7 $$07722-84-1$$2NLM Chemicals$$aHydrogen Peroxide
000005895 650_7 $$0EC 1.11.1.10$$2NLM Chemicals$$aChloride Peroxidase
000005895 650_7 $$0EC 1.4.-$$2NLM Chemicals$$aAmino Acid Oxidoreductases
000005895 650_7 $$2WoSType$$aJ
000005895 7001_ $$0P:(DE-HGF)0$$aGreiner, L.$$b1
000005895 7001_ $$0P:(DE-HGF)0$$aLeitner, W.$$b2
000005895 7001_ $$0P:(DE-Juel1)129071$$aWandrey, C.$$b3$$uFZJ
000005895 7001_ $$0P:(DE-Juel1)VDB978$$aLütz, S.$$b4$$uFZJ
000005895 773__ $$0PERI:(DE-600)1478547-x$$a10.1002/chem.200901046$$gVol. 15, p. 11692 - 11700$$p11692 - 11700$$q15<11692 - 11700$$tChemistry$$v15$$x0947-6539$$y2009
000005895 8567_ $$uhttp://dx.doi.org/10.1002/chem.200901046
000005895 909CO $$ooai:juser.fz-juelich.de:5895$$pVDB
000005895 915__ $$0StatID:(DE-HGF)0010$$aJCR/ISI refereed
000005895 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer review
000005895 9141_ $$y2009
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000005895 9201_ $$0I:(DE-Juel1)VDB56$$gIBT$$kIBT-2$$lBiotechnologie 2$$x0$$zab 31.10.10 weitergeführt IBG-1
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