% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Kohlmann:5895,
      author       = {Kohlmann, C. and Greiner, L. and Leitner, W. and Wandrey,
                      C. and Lütz, S.},
      title        = {{I}onic {L}iquides as {P}erformance {A}dditives for
                      {E}lectroenzymatic {S}yntheses},
      journal      = {Chemistry},
      volume       = {15},
      issn         = {0947-6539},
      address      = {Weinheim},
      publisher    = {Wiley-VCH},
      reportid     = {PreJuSER-5895},
      pages        = {11692 - 11700},
      year         = {2009},
      note         = {The authors thank Lilia Harter, Stephanie Corsten and
                      Zubeyda Dogan for excellent work in the lab and the GK 1166
                      "BioNoCo" for fruitful discussion and funding. L.G. thanks
                      the cluster of excellence "Tailor-Made Fuels from Biomass"
                      (TMFB) for support.},
      abstract     = {Electroenzymatic syntheses combine oxidoreductase-catalysed
                      reactions with electrochemical reactant supply. The use of
                      ionic liquids as performance additives can contribute to
                      overcoming existing limitations of these syntheses. Here, we
                      report on the influence of different water-miscible ionic
                      liquids on critical parameters such as conductivity,
                      biocatalyst activity and stability or substrate solubility
                      for three typical electroenzymatic syntheses. In these
                      investigations promising ionic liquids were identified and
                      have been used as additives for batch electrolyses on
                      preparative scale for the three electroenzymatic systems. It
                      was possible to improve the space-time-yield for the
                      electrochemical regeneration of NADPH by a factor of three.
                      For an amino acid oxidase catalysed resolution of a
                      methionine racemate with ferrocene-mediated electrochemical
                      regeneration of the enzyme-bound cofactor FAD a $50\%$
                      increase in space time yield and $140\%$ increase in
                      catalyst utilisation (TTN) were achieved. Furthermore, for
                      the chloroperoxidase-catalysed synthesis of
                      (R)-phenylmethylsulfoxide with electrochemical generation of
                      the required cosubstrate H2O2 the space time yield and the
                      catalyst utilisation were improved by a factor of up to 4.2
                      depending on the ionic liquids used.},
      keywords     = {Amino Acid Oxidoreductases: metabolism / Biocatalysis /
                      Chloride Peroxidase: metabolism / Electrochemical Techniques
                      / Flavin-Adenine Dinucleotide: metabolism / Hydrogen
                      Peroxide: metabolism / Ionic Liquids: chemistry / NADP:
                      metabolism / Solubility / Ionic Liquids (NLM Chemicals) /
                      Flavin-Adenine Dinucleotide (NLM Chemicals) / NADP (NLM
                      Chemicals) / Hydrogen Peroxide (NLM Chemicals) / Chloride
                      Peroxidase (NLM Chemicals) / Amino Acid Oxidoreductases (NLM
                      Chemicals) / J (WoSType)},
      cin          = {IBT-2},
      ddc          = {540},
      cid          = {I:(DE-Juel1)VDB56},
      pnm          = {Biotechnologie},
      pid          = {G:(DE-Juel1)FUEK410},
      shelfmark    = {Chemistry, Multidisciplinary},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:19777513},
      UT           = {WOS:000271992100033},
      doi          = {10.1002/chem.200901046},
      url          = {https://juser.fz-juelich.de/record/5895},
}