Journal Article

PreJuSER-6137

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Colloidal particles composed of amphiphilic molecules binding gadolinium complexes and peptides as tumor-specific contrast agents in MRI: physico-chemical characterization.

Vacarro, M. ; Magiapia, G. ; Radulescu, A.FZJ* ; Schillen, K. ; D'Errico, G. ; Morelli, G. ; Paduano, L.

2009
Royal Society of Chemistry (RSC) Cambridge

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Please use a persistent id in citations: doi:10.1039/b820804b

Abstract: This article highlights our recent achievements on the development and upgrade of new potential tumor-specific contrast agents for magnetic resonance imaging (MRI) based on gadolinium complexes and peptides, assemblied in amphiphilic supramolecular aggregates. The physico-chemical characterization of these aggregates provides novel and interesting opportunities to investigate surfactant aggregation properties, that may be exploited in several applications such as in medical diagnostics or in drug and gene delivery.

Keyword(s): J

Note: We thank CSGI (Consorzio inter-universitario per sviuppo dei Sistemi a Grande Interfase) and MIUR (PRIN-2006) for financial support. We thank Dr Antonella Accardo and Diego Tesauro for the synthesis of unimers. MV, LP, G. M wish to thank the Forschungszentrum Julich, Hahn Meitner Institut, Rutherofrd Appleton Laboratory and the Leon Brillouin Laboratory for providing beam time. Most of the SANS experiments were supported by the European Commission, NMI3 contract RII3-CT-2003-505925. The authors are also grateful to Gunnel Karlsson for the cryo-TEM imaging.

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Contributing Institute(s):

1. Streumethoden (IFF-4)
2. Neutronenstreuung (IFF-5)
3. JCNS (Jülich Centre for Neutron Science JCNS (JCNS) ; JCNS)

Research Program(s):

1. Kondensierte Materie (P54)
2. Großgeräte für die Forschung mit Photonen, Neutronen und Ionen (PNI) (P55)

Experiment(s):

1. KWS-2: Small angle scattering diffractometer (NL3ao)

Appears in the scientific report 2009

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