TY  - JOUR
AU  - Funke, S. A.
AU  - Birkmann, E.
AU  - Henke, F.
AU  - Görtz, P.
AU  - Lange-Asschenfeldt, C.
AU  - Riesner, D.
AU  - Willbold, D.
TI  - An Ultra-Sensitive Assay For Diagnosis Of Alzheimer's Disease
JO  - Rejuvenation research
VL  - 11
SN  - 1549-1684
CY  - Larchmont, NY
PB  - Liebert
M1  - PreJuSER-62862
SP  - 315 - 318
PY  - 2008
N1  - Record converted from VDB: 12.11.2012
AB  - Alzheimer's disease (AD) is a chronic neurodegenerative disorder and the most common cause of dementia. Aging is among the most significant risk factors. Today, AD can be diagnosed with certainty only post mortem, detecting insoluble beta-amyloid peptide (Abeta) aggregates in the patient's brain tissue. We have developed an ultrasensitive assay for early and non-invasive diagnosis of AD. This highly specific and sensitive assay uses fluorescence correlation spectroscopy (FCS) and is sensitive enough to detect even single aggregates in body fluids of AD patients. We investigate the correlation of aggregated Abeta concentrations in body fluids with clinical symptoms of AD.
KW  - Alzheimer Disease: diagnosis
KW  - Amyloid beta-Peptides: cerebrospinal fluid
KW  - Amyloid beta-Peptides: chemical synthesis
KW  - Amyloid beta-Peptides: chemistry
KW  - Humans
KW  - Protein Structure, Quaternary
KW  - Sensitivity and Specificity
KW  - Spectrometry, Fluorescence: methods
KW  - Amyloid beta-Peptides (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:18328004
UR  - <Go to ISI:>//WOS:000255773200008
DO  - DOI:10.1089/rej.2008.0670
UR  - https://juser.fz-juelich.de/record/62862
ER  -