Journal Article

PreJuSER-62862

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png An Ultra-Sensitive Assay For Diagnosis Of Alzheimer's Disease

Funke, S. A.FZJ* ; Birkmann, E.FZJ* ; Henke, F. ; Görtz, P. ; Lange-Asschenfeldt, C. ; Riesner, D. ; Willbold, D.FZJ*

2008
Liebert Larchmont, NY

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Please use a persistent id in citations: doi:10.1089/rej.2008.0670

Abstract: Alzheimer's disease (AD) is a chronic neurodegenerative disorder and the most common cause of dementia. Aging is among the most significant risk factors. Today, AD can be diagnosed with certainty only post mortem, detecting insoluble beta-amyloid peptide (Abeta) aggregates in the patient's brain tissue. We have developed an ultrasensitive assay for early and non-invasive diagnosis of AD. This highly specific and sensitive assay uses fluorescence correlation spectroscopy (FCS) and is sensitive enough to detect even single aggregates in body fluids of AD patients. We investigate the correlation of aggregated Abeta concentrations in body fluids with clinical symptoms of AD.

Keyword(s): Alzheimer Disease: diagnosis (MeSH) ; Amyloid beta-Peptides: cerebrospinal fluid (MeSH) ; Amyloid beta-Peptides: chemical synthesis (MeSH) ; Amyloid beta-Peptides: chemistry (MeSH) ; Humans (MeSH) ; Protein Structure, Quaternary (MeSH) ; Sensitivity and Specificity (MeSH) ; Spectrometry, Fluorescence: methods (MeSH) ; Amyloid beta-Peptides ; J

Note: Record converted from VDB: 12.11.2012

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Contributing Institute(s):

1. Molekulare Biophysik (INB-2)

Research Program(s):

1. Funktion und Dysfunktion des Nervensystems (P33)

Appears in the scientific report 2008

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