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@ARTICLE{Funke:62862,
      author       = {Funke, S. A. and Birkmann, E. and Henke, F. and Görtz, P.
                      and Lange-Asschenfeldt, C. and Riesner, D. and Willbold, D.},
      title        = {{A}n {U}ltra-{S}ensitive {A}ssay {F}or {D}iagnosis {O}f
                      {A}lzheimer's {D}isease},
      journal      = {Rejuvenation research},
      volume       = {11},
      issn         = {1549-1684},
      address      = {Larchmont, NY},
      publisher    = {Liebert},
      reportid     = {PreJuSER-62862},
      pages        = {315 - 318},
      year         = {2008},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {Alzheimer's disease (AD) is a chronic neurodegenerative
                      disorder and the most common cause of dementia. Aging is
                      among the most significant risk factors. Today, AD can be
                      diagnosed with certainty only post mortem, detecting
                      insoluble beta-amyloid peptide (Abeta) aggregates in the
                      patient's brain tissue. We have developed an ultrasensitive
                      assay for early and non-invasive diagnosis of AD. This
                      highly specific and sensitive assay uses fluorescence
                      correlation spectroscopy (FCS) and is sensitive enough to
                      detect even single aggregates in body fluids of AD patients.
                      We investigate the correlation of aggregated Abeta
                      concentrations in body fluids with clinical symptoms of AD.},
      keywords     = {Alzheimer Disease: diagnosis / Amyloid beta-Peptides:
                      cerebrospinal fluid / Amyloid beta-Peptides: chemical
                      synthesis / Amyloid beta-Peptides: chemistry / Humans /
                      Protein Structure, Quaternary / Sensitivity and Specificity
                      / Spectrometry, Fluorescence: methods / Amyloid
                      beta-Peptides (NLM Chemicals) / J (WoSType)},
      cin          = {INB-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)VDB805},
      pnm          = {Funktion und Dysfunktion des Nervensystems},
      pid          = {G:(DE-Juel1)FUEK409},
      shelfmark    = {Geriatrics $\&$ Gerontology},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:18328004},
      UT           = {WOS:000255773200008},
      doi          = {10.1089/rej.2008.0670},
      url          = {https://juser.fz-juelich.de/record/62862},
}