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000062921 0247_ $$2DOI$$a10.1089/rej.2008.0697
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000062921 037__ $$aPreJuSER-62921
000062921 041__ $$aeng
000062921 082__ $$a610
000062921 084__ $$2WoS$$aGeriatrics & Gerontology
000062921 1001_ $$0P:(DE-Juel1)VDB65870$$aBirkmann, E.$$b0$$uFZJ
000062921 245__ $$aA highly sensitive diagnostic assay for aggregate-related diseases, including prion diseases and Alzheimer's disease
000062921 260__ $$aLarchmont, NY$$bLiebert$$c2008
000062921 300__ $$a359 - 363
000062921 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000062921 440_0 $$018202$$aRejuvenation Research$$v11$$x1549-1684$$y2
000062921 500__ $$aRecord converted from VDB: 12.11.2012
000062921 520__ $$aPrion diseases, Alzheimer's disease, and Parkinson's disease are age-related neurodegenerative diseases that are characterized by the formation of protein aggregates during the progress of the disease. Although it is still not known whether these aggregates are causative for, or symptoms of, the disease. Many studies show that aggregates or even oligomers of the according proteins are neurotoxic and thus may lead to neurodegeneration. To understand disease-associated or causative mechanisms in respect to protein aggregation, an ultrasensitive tool to quantify these disease-related aggregates is required. In this study we introduce a specificity-enhanced version of surface-FIDA as an approach to count even single aggregates in tissue homogenate and body liquids.
000062921 536__ $$0G:(DE-Juel1)FUEK409$$2G:(DE-HGF)$$aFunktion und Dysfunktion des Nervensystems$$cP33$$x0
000062921 588__ $$aDataset connected to Web of Science, Pubmed
000062921 650_2 $$2MeSH$$aAlzheimer Disease: diagnosis
000062921 650_2 $$2MeSH$$aAnimals
000062921 650_2 $$2MeSH$$aBiological Assay: methods
000062921 650_2 $$2MeSH$$aCattle
000062921 650_2 $$2MeSH$$aPrion Diseases: diagnosis
000062921 650_2 $$2MeSH$$aProtein Structure, Quaternary
000062921 650_2 $$2MeSH$$aSensitivity and Specificity
000062921 650_7 $$2WoSType$$aJ
000062921 7001_ $$0P:(DE-Juel1)VDB65871$$aHenke, F.$$b1$$uFZJ
000062921 7001_ $$0P:(DE-Juel1)VDB65869$$aFunke, S. A.$$b2$$uFZJ
000062921 7001_ $$0P:(DE-HGF)0$$aBannach, O.$$b3
000062921 7001_ $$0P:(DE-HGF)0$$aRiesner, D.$$b4
000062921 7001_ $$0P:(DE-Juel1)132029$$aWillbold, D.$$b5$$uFZJ
000062921 773__ $$0PERI:(DE-600)2155984-3$$a10.1089/rej.2008.0697$$gVol. 11, p. 359 - 363$$p359 - 363$$q11<359 - 363$$tRejuvenation research$$v11$$x1549-1684$$y2008
000062921 8567_ $$uhttp://dx.doi.org/10.1089/rej.2008.0697
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000062921 9141_ $$y2008
000062921 915__ $$0StatID:(DE-HGF)0010$$aJCR/ISI refereed
000062921 9201_ $$0I:(DE-Juel1)VDB805$$d31.12.2008$$gINB$$kINB-2$$lMolekulare Biophysik$$x0
000062921 9201_ $$0I:(DE-Juel1)VDB1045$$gJARA$$kJARA-SIM$$lJülich-Aachen Research Alliance - Simulation Sciences$$x1
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