Journal Article

PreJuSER-62921

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png A highly sensitive diagnostic assay for aggregate-related diseases, including prion diseases and Alzheimer's disease

Birkmann, E.FZJ* ; Henke, F.FZJ* ; Funke, S. A.FZJ* ; Bannach, O. ; Riesner, D. ; Willbold, D.FZJ*

2008
Liebert Larchmont, NY

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Please use a persistent id in citations: doi:10.1089/rej.2008.0697

Abstract: Prion diseases, Alzheimer's disease, and Parkinson's disease are age-related neurodegenerative diseases that are characterized by the formation of protein aggregates during the progress of the disease. Although it is still not known whether these aggregates are causative for, or symptoms of, the disease. Many studies show that aggregates or even oligomers of the according proteins are neurotoxic and thus may lead to neurodegeneration. To understand disease-associated or causative mechanisms in respect to protein aggregation, an ultrasensitive tool to quantify these disease-related aggregates is required. In this study we introduce a specificity-enhanced version of surface-FIDA as an approach to count even single aggregates in tissue homogenate and body liquids.

Keyword(s): Alzheimer Disease: diagnosis (MeSH) ; Animals (MeSH) ; Biological Assay: methods (MeSH) ; Cattle (MeSH) ; Prion Diseases: diagnosis (MeSH) ; Protein Structure, Quaternary (MeSH) ; Sensitivity and Specificity (MeSH) ; J

Note: Record converted from VDB: 12.11.2012

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Contributing Institute(s):

1. Molekulare Biophysik (INB-2)
2. Jülich-Aachen Research Alliance - Simulation Sciences (JARA-SIM)

Research Program(s):

1. Funktion und Dysfunktion des Nervensystems (P33)

Appears in the scientific report 2008

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