TY  - JOUR
AU  - Birkmann, E.
AU  - Henke, F.
AU  - Funke, S. A.
AU  - Bannach, O.
AU  - Riesner, D.
AU  - Willbold, D.
TI  - A highly sensitive diagnostic assay for aggregate-related diseases, including prion diseases and Alzheimer's disease
JO  - Rejuvenation research
VL  - 11
SN  - 1549-1684
CY  - Larchmont, NY
PB  - Liebert
M1  - PreJuSER-62921
SP  - 359 - 363
PY  - 2008
N1  - Record converted from VDB: 12.11.2012
AB  - Prion diseases, Alzheimer's disease, and Parkinson's disease are age-related neurodegenerative diseases that are characterized by the formation of protein aggregates during the progress of the disease. Although it is still not known whether these aggregates are causative for, or symptoms of, the disease. Many studies show that aggregates or even oligomers of the according proteins are neurotoxic and thus may lead to neurodegeneration. To understand disease-associated or causative mechanisms in respect to protein aggregation, an ultrasensitive tool to quantify these disease-related aggregates is required. In this study we introduce a specificity-enhanced version of surface-FIDA as an approach to count even single aggregates in tissue homogenate and body liquids.
KW  - Alzheimer Disease: diagnosis
KW  - Animals
KW  - Biological Assay: methods
KW  - Cattle
KW  - Prion Diseases: diagnosis
KW  - Protein Structure, Quaternary
KW  - Sensitivity and Specificity
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:18442323
UR  - <Go to ISI:>//WOS:000255773200014
DO  - DOI:10.1089/rej.2008.0697
UR  - https://juser.fz-juelich.de/record/62921
ER  -