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@ARTICLE{Birkmann:62921,
      author       = {Birkmann, E. and Henke, F. and Funke, S. A. and Bannach, O.
                      and Riesner, D. and Willbold, D.},
      title        = {{A} highly sensitive diagnostic assay for aggregate-related
                      diseases, including prion diseases and {A}lzheimer's
                      disease},
      journal      = {Rejuvenation research},
      volume       = {11},
      issn         = {1549-1684},
      address      = {Larchmont, NY},
      publisher    = {Liebert},
      reportid     = {PreJuSER-62921},
      pages        = {359 - 363},
      year         = {2008},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {Prion diseases, Alzheimer's disease, and Parkinson's
                      disease are age-related neurodegenerative diseases that are
                      characterized by the formation of protein aggregates during
                      the progress of the disease. Although it is still not known
                      whether these aggregates are causative for, or symptoms of,
                      the disease. Many studies show that aggregates or even
                      oligomers of the according proteins are neurotoxic and thus
                      may lead to neurodegeneration. To understand
                      disease-associated or causative mechanisms in respect to
                      protein aggregation, an ultrasensitive tool to quantify
                      these disease-related aggregates is required. In this study
                      we introduce a specificity-enhanced version of surface-FIDA
                      as an approach to count even single aggregates in tissue
                      homogenate and body liquids.},
      keywords     = {Alzheimer Disease: diagnosis / Animals / Biological Assay:
                      methods / Cattle / Prion Diseases: diagnosis / Protein
                      Structure, Quaternary / Sensitivity and Specificity / J
                      (WoSType)},
      cin          = {INB-2 / JARA-SIM},
      ddc          = {610},
      cid          = {I:(DE-Juel1)VDB805 / I:(DE-Juel1)VDB1045},
      pnm          = {Funktion und Dysfunktion des Nervensystems},
      pid          = {G:(DE-Juel1)FUEK409},
      shelfmark    = {Geriatrics $\&$ Gerontology},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:18442323},
      UT           = {WOS:000255773200014},
      doi          = {10.1089/rej.2008.0697},
      url          = {https://juser.fz-juelich.de/record/62921},
}