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001     62921
005     20200402210515.0
024 7 _ |2 pmid
|a pmid:18442323
024 7 _ |2 DOI
|a 10.1089/rej.2008.0697
024 7 _ |2 WOS
|a WOS:000255773200014
037 _ _ |a PreJuSER-62921
041 _ _ |a eng
082 _ _ |a 610
084 _ _ |2 WoS
|a Geriatrics & Gerontology
100 1 _ |a Birkmann, E.
|b 0
|u FZJ
|0 P:(DE-Juel1)VDB65870
245 _ _ |a A highly sensitive diagnostic assay for aggregate-related diseases, including prion diseases and Alzheimer's disease
260 _ _ |a Larchmont, NY
|b Liebert
|c 2008
300 _ _ |a 359 - 363
336 7 _ |a Journal Article
|0 PUB:(DE-HGF)16
|2 PUB:(DE-HGF)
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|0 0
|2 EndNote
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a article
|2 DRIVER
440 _ 0 |a Rejuvenation Research
|x 1549-1684
|0 18202
|y 2
|v 11
500 _ _ |a Record converted from VDB: 12.11.2012
520 _ _ |a Prion diseases, Alzheimer's disease, and Parkinson's disease are age-related neurodegenerative diseases that are characterized by the formation of protein aggregates during the progress of the disease. Although it is still not known whether these aggregates are causative for, or symptoms of, the disease. Many studies show that aggregates or even oligomers of the according proteins are neurotoxic and thus may lead to neurodegeneration. To understand disease-associated or causative mechanisms in respect to protein aggregation, an ultrasensitive tool to quantify these disease-related aggregates is required. In this study we introduce a specificity-enhanced version of surface-FIDA as an approach to count even single aggregates in tissue homogenate and body liquids.
536 _ _ |a Funktion und Dysfunktion des Nervensystems
|c P33
|2 G:(DE-HGF)
|0 G:(DE-Juel1)FUEK409
|x 0
588 _ _ |a Dataset connected to Web of Science, Pubmed
650 _ 2 |2 MeSH
|a Alzheimer Disease: diagnosis
650 _ 2 |2 MeSH
|a Animals
650 _ 2 |2 MeSH
|a Biological Assay: methods
650 _ 2 |2 MeSH
|a Cattle
650 _ 2 |2 MeSH
|a Prion Diseases: diagnosis
650 _ 2 |2 MeSH
|a Protein Structure, Quaternary
650 _ 2 |2 MeSH
|a Sensitivity and Specificity
650 _ 7 |a J
|2 WoSType
700 1 _ |a Henke, F.
|b 1
|u FZJ
|0 P:(DE-Juel1)VDB65871
700 1 _ |a Funke, S. A.
|b 2
|u FZJ
|0 P:(DE-Juel1)VDB65869
700 1 _ |a Bannach, O.
|b 3
|0 P:(DE-HGF)0
700 1 _ |a Riesner, D.
|b 4
|0 P:(DE-HGF)0
700 1 _ |a Willbold, D.
|b 5
|u FZJ
|0 P:(DE-Juel1)132029
773 _ _ |a 10.1089/rej.2008.0697
|g Vol. 11, p. 359 - 363
|p 359 - 363
|q 11<359 - 363
|0 PERI:(DE-600)2155984-3
|t Rejuvenation research
|v 11
|y 2008
|x 1549-1684
856 7 _ |u http://dx.doi.org/10.1089/rej.2008.0697
909 C O |o oai:juser.fz-juelich.de:62921
|p VDB
913 1 _ |k P33
|v Funktion und Dysfunktion des Nervensystems
|l Funktion und Dysfunktion des Nervensystems
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|x 0
914 1 _ |y 2008
915 _ _ |0 StatID:(DE-HGF)0010
|a JCR/ISI refereed
920 1 _ |k INB-2
|l Molekulare Biophysik
|d 31.12.2008
|g INB
|0 I:(DE-Juel1)VDB805
|x 0
920 1 _ |k JARA-SIM
|l Jülich-Aachen Research Alliance - Simulation Sciences
|g JARA
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970 _ _ |a VDB:(DE-Juel1)99860
980 _ _ |a VDB
980 _ _ |a ConvertedRecord
980 _ _ |a journal
980 _ _ |a I:(DE-Juel1)ISB-2-20090406
980 _ _ |a I:(DE-Juel1)VDB1045
980 _ _ |a UNRESTRICTED
980 _ _ |a I:(DE-Juel1)ICS-6-20110106
981 _ _ |a I:(DE-Juel1)IBI-7-20200312
981 _ _ |a I:(DE-Juel1)ISB-2-20090406
981 _ _ |a I:(DE-Juel1)VDB1045
981 _ _ |a I:(DE-Juel1)ICS-6-20110106

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