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@ARTICLE{Frster:7177,
      author       = {Förster, M. and Laabs, V. and Lamshöft, M. and Groeneweg,
                      J. and Zühlke, S. and Spiteller, M. and Krauss, M. and
                      Kaupenjohann, M. and Amelung, W.},
      title        = {{S}equestration of manure-applied sulfadiazine in soils},
      journal      = {Environmental Science $\&$ Technology},
      volume       = {43},
      issn         = {0013-936X},
      address      = {Columbus, Ohio},
      publisher    = {American Chemical Society},
      reportid     = {PreJuSER-7177},
      pages        = {1824 - 1830},
      year         = {2009},
      note         = {We thank U. Kutsch for help with laboratory analyses of
                      soil samples and Bayer CropScience AG for conduction of the
                      radioactive SDZ medication experiment. M. Matthies, J.
                      KJasmeier, and C. Zarfl are thanked for constructive advice.
                      The project was funded by the German Research Foundation
                      (DFG) within the Research Unit FOR566 "Veterinary medicines
                      in soils: Basic research for risk assessment" (AM134/6-2).},
      abstract     = {It is not the total but the (bio)accessible concentration
                      of veterinary medicines that determines their toxicity in
                      the environment We elucidate the changes in
                      (bio)accessibility of manure-applied sulfadiazine (SDZ) with
                      increasing contact time in soil. Fattening pigs were
                      medicated with IT-labeled SDZ, and the contaminated manure
                      (fresh and aged) was amended to 2 soil types (Cambisol,
                      Luvisol) and incubated for 218 days at 10 degrees C in the
                      dark. Antibiotic residues of different bioaccessibility were
                      approached by sequential extractions with 0.01 M CaCl2
                      (CaCl2 fraction), methanol (MeOH fraction) and finally
                      acetonitrile/water (residual fraction, microwave extraction
                      at 150 degrees C). In each fraction, total radioactivity,
                      SDZ, and its major metabolites were quantified. The results
                      showed that both SDZ and,to a lesser extent
                      4-hydroxysulfadiazine (4-OH-SDZ) were rapidly reformed from
                      N-acetylsulfadiazine(N-ac-SDZ) during the first 2-4 weeks
                      after fresh manure application, i.e., the N-acetylated
                      metabolite does not sequester in soil to a significant
                      extent. Yet, the water and methanol extractable SDZ and
                      4-OH-SDZ also dissipated rapidly (DT50 6.0-32 days) for the
                      fresh manure treatment with similar rate constants for both
                      soil types. In the residual fractions, however, the
                      concentrations of both compounds increased with time. We
                      conclude that the residual fraction comprises the
                      sequestered pool of SDZ and its hydroxylated metabolite.
                      There they are entrapped and may persist in soil for several
                      years. Including the residual fraction into fate studies
                      thus yields dissipation half-lives of SDZ which exceed those
                      previously reported for sulfonamides by a factor of about
                      100.},
      keywords     = {J (WoSType)},
      cin          = {ICG-4},
      ddc          = {050},
      cid          = {I:(DE-Juel1)VDB793},
      pnm          = {Terrestrische Umwelt},
      pid          = {G:(DE-Juel1)FUEK407},
      shelfmark    = {Engineering, Environmental / Environmental Sciences},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000264108800029},
      doi          = {10.1021/es8026538},
      url          = {https://juser.fz-juelich.de/record/7177},
}