Journal Article

PreJuSER-7177

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Sequestration of manure-applied sulfadiazine in soils

Förster, M. ; Laabs, V. ; Lamshöft, M. ; Groeneweg, J.FZJ* ; Zühlke, S. ; Spiteller, M. ; Krauss, M.FZJ* ; Kaupenjohann, M. ; Amelung, W.

2009
American Chemical Society Columbus, Ohio

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Please use a persistent id in citations: doi:10.1021/es8026538

Abstract: It is not the total but the (bio)accessible concentration of veterinary medicines that determines their toxicity in the environment We elucidate the changes in (bio)accessibility of manure-applied sulfadiazine (SDZ) with increasing contact time in soil. Fattening pigs were medicated with IT-labeled SDZ, and the contaminated manure (fresh and aged) was amended to 2 soil types (Cambisol, Luvisol) and incubated for 218 days at 10 degrees C in the dark. Antibiotic residues of different bioaccessibility were approached by sequential extractions with 0.01 M CaCl2 (CaCl2 fraction), methanol (MeOH fraction) and finally acetonitrile/water (residual fraction, microwave extraction at 150 degrees C). In each fraction, total radioactivity, SDZ, and its major metabolites were quantified. The results showed that both SDZ and,to a lesser extent 4-hydroxysulfadiazine (4-OH-SDZ) were rapidly reformed from N-acetylsulfadiazine(N-ac-SDZ) during the first 2-4 weeks after fresh manure application, i.e., the N-acetylated metabolite does not sequester in soil to a significant extent. Yet, the water and methanol extractable SDZ and 4-OH-SDZ also dissipated rapidly (DT50 6.0-32 days) for the fresh manure treatment with similar rate constants for both soil types. In the residual fractions, however, the concentrations of both compounds increased with time. We conclude that the residual fraction comprises the sequestered pool of SDZ and its hydroxylated metabolite. There they are entrapped and may persist in soil for several years. Including the residual fraction into fate studies thus yields dissipation half-lives of SDZ which exceed those previously reported for sulfonamides by a factor of about 100.

Keyword(s): J

Note: We thank U. Kutsch for help with laboratory analyses of soil samples and Bayer CropScience AG for conduction of the radioactive SDZ medication experiment. M. Matthies, J. KJasmeier, and C. Zarfl are thanked for constructive advice. The project was funded by the German Research Foundation (DFG) within the Research Unit FOR566 "Veterinary medicines in soils: Basic research for risk assessment" (AM134/6-2).

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Research Program(s):

1. Terrestrische Umwelt (P24)

Appears in the scientific report 2009

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Database coverage:
JCR ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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