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024 7 _ |a pmid:19553452
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024 7 _ |a 10.1523/JNEUROSCI.0203-09.2009
|2 DOI
024 7 _ |a WOS:000267339000019
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024 7 _ |a 2128/20598
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037 _ _ |a PreJuSER-7950
041 _ _ |a eng
082 _ _ |a 590
084 _ _ |2 WoS
|a Neurosciences
100 1 _ |0 P:(DE-HGF)0
|a Kukolja, J.
|b 0
245 _ _ |a Cholinergic stimulation enhances neural activity associated with encoding but reduces neural activity associated with retrieval in humans
260 _ _ |a Washington, DC
|b Soc.
|c 2009
300 _ _ |a 8119 - 8128
336 7 _ |a Journal Article
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336 7 _ |a article
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440 _ 0 |0 3603
|a Journal of Neuroscience
|v 29
|x 0270-6474
|y 5
500 _ _ |a This work was supported by a grant of the Deutsche Forschungsgemeinschaft (DFG-KFO 112, TP8) to G. R. F. and C. M. T. We thank all our volunteers. We are grateful to our colleagues of the MR and Cognitive Neurology groups for valuable support. We thank Laura Amort and Birte Berger for neuropsychological testing.
520 _ _ |a The cerebral cholinergic system is centrally involved in memory formation. Studies in rodents suggest that cholinergic stimulation may facilitate encoding of new information but may interfere with retrieval. We investigated the effect of cholinergic stimulation on encoding and retrieval of episodic memory in humans. We also tested whether the putative benefit of cholinergic stimulation on memory function depends on individual baseline performance. Since such effects were expected to be greatest in an older population resulting from an age-related degeneration of the cholinergic system, we recruited 22 healthy older subjects (51-68 years) for an event-related functional magnetic resonance imaging experiment. In two separate scanning sessions, subjects encoded and retrieved items and their spatial context under cholinergic stimulation or placebo with the acetylcholine-esterase inhibitor physostigmine or saline being administered intravenously in a double-blind cross-over design. Baseline performance was recorded at a separate occasion without scanning. Cholinergic stimulation enhanced neural activity for successful versus unsuccessful spatial context encoding in the right hippocampus but reduced activity for successful versus unsuccessful spatial context retrieval in the right amygdala. These data may bridge the gap between rodent and human studies by showing that also in man cholinergic stimulation enhances encoding but interferes with retrieval on a neural level. Furthermore, baseline performance negatively correlated with the effect of cholinergic stimulation. Thus, participants who were worse at baseline benefited more from cholinergic stimulation than those who had better baseline values, indicating that a cholinergic deficit contributes to the memory decline even in healthy older subjects.
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588 _ _ |a Dataset connected to Web of Science, Pubmed
650 _ 2 |2 MeSH
|a Aged
650 _ 2 |2 MeSH
|a Amygdala: drug effects
650 _ 2 |2 MeSH
|a Amygdala: physiology
650 _ 2 |2 MeSH
|a Analysis of Variance
650 _ 2 |2 MeSH
|a Cholinesterase Inhibitors: administration & dosage
650 _ 2 |2 MeSH
|a Cholinesterase Inhibitors: pharmacology
650 _ 2 |2 MeSH
|a Cross-Over Studies
650 _ 2 |2 MeSH
|a Double-Blind Method
650 _ 2 |2 MeSH
|a Female
650 _ 2 |2 MeSH
|a Functional Laterality: drug effects
650 _ 2 |2 MeSH
|a Hippocampus: drug effects
650 _ 2 |2 MeSH
|a Hippocampus: physiology
650 _ 2 |2 MeSH
|a Humans
650 _ 2 |2 MeSH
|a Injections, Intravenous
650 _ 2 |2 MeSH
|a Magnetic Resonance Imaging
650 _ 2 |2 MeSH
|a Male
650 _ 2 |2 MeSH
|a Memory: drug effects
650 _ 2 |2 MeSH
|a Middle Aged
650 _ 2 |2 MeSH
|a Neuropsychological Tests
650 _ 2 |2 MeSH
|a Physostigmine: administration & dosage
650 _ 2 |2 MeSH
|a Physostigmine: pharmacology
650 _ 2 |2 MeSH
|a Psychomotor Performance: drug effects
650 _ 2 |2 MeSH
|a Reaction Time: drug effects
650 _ 2 |2 MeSH
|a Space Perception: drug effects
650 _ 2 |2 MeSH
|a Spatial Behavior: drug effects
650 _ 7 |0 0
|2 NLM Chemicals
|a Cholinesterase Inhibitors
650 _ 7 |0 57-47-6
|2 NLM Chemicals
|a Physostigmine
650 _ 7 |2 WoSType
|a J
700 1 _ |0 P:(DE-HGF)0
|a Thiel, C.M.
|b 1
700 1 _ |0 P:(DE-Juel1)131720
|a Fink, G. R.
|b 2
|u FZJ
773 _ _ |0 PERI:(DE-600)1475274-8
|a 10.1523/JNEUROSCI.0203-09.2009
|g Vol. 29, p. 8119 - 8128
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|t The @journal of neuroscience
|v 29
|x 0270-6474
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856 7 _ |u http://dx.doi.org/10.1523/JNEUROSCI.0203-09.2009
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