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@ARTICLE{Stingaciu:807644,
      author       = {Stingaciu, Laura and Ivanova, Oxana and Ohl, Michael and
                      Biehl, Ralf and Richter, Dieter},
      title        = {{F}ast antibody fragment motion: flexible linkers act as
                      entropic spring},
      journal      = {Scientific reports},
      volume       = {6},
      issn         = {2045-2322},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {FZJ-2016-02131},
      pages        = {22148 - 1-13},
      year         = {2016},
      abstract     = {A flexible linker region between three fragments allows
                      antibodies to adjust their binding sites to an antigen or
                      receptor. Using Neutron Spin Echo Spectroscopy we observed
                      fragment motion on a timescale of 7 ns with motional
                      amplitudes of about 1 nm relative to each other. The
                      mechanistic complexity of the linker region can be described
                      by a spring model with Brownian motion of the fragments in a
                      harmonic potential. Displacements, timescale, friction and
                      force constant of the underlying dynamics are accessed. The
                      force constant exhibits a similar strength to an entropic
                      spring, with friction of the fragment matching the unbound
                      state. The observed fast motions are fluctuations in
                      pre-existing equilibrium configurations. The Brownian motion
                      of domains in a harmonic potential is the appropriate model
                      to examine functional hinge motions dependent on the
                      structural topology and highlights the role of internal
                      forces and friction to function.},
      cin          = {JCNS (München) ; Jülich Centre for Neutron Science JCNS
                      (München) ; JCNS-FRM-II / ICS-1 / Neutronenstreuung ;
                      JCNS-1 / JCNS-SNS},
      ddc          = {000},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)ICS-1-20110106 / I:(DE-Juel1)JCNS-1-20110106 /
                      I:(DE-Juel1)JCNS-SNS-20110128},
      pnm          = {6215 - Soft Matter, Health and Life Sciences (POF3-621) /
                      6G4 - Jülich Centre for Neutron Research (JCNS) (POF3-623)
                      / 6G15 - FRM II / MLZ (POF3-6G15)},
      pid          = {G:(DE-HGF)POF3-6215 / G:(DE-HGF)POF3-6G4 /
                      G:(DE-HGF)POF3-6G15},
      experiment   = {EXP:(DE-MLZ)J-NSE-20140101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000372914800001},
      pubmed       = {pmid:27020739},
      doi          = {10.1038/srep22148},
      url          = {https://juser.fz-juelich.de/record/807644},
}