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| 001 | 807644 | ||
| 005 | 20240619092003.0 | ||
| 024 | 7 | _ | |a 10.1038/srep22148 |2 doi |
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| 100 | 1 | _ | |a Stingaciu, Laura |0 P:(DE-Juel1)129542 |b 0 |u fzj |
| 245 | _ | _ | |a Fast antibody fragment motion: flexible linkers act as entropic spring |
| 260 | _ | _ | |a London |c 2016 |b Nature Publishing Group |
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| 520 | _ | _ | |a A flexible linker region between three fragments allows antibodies to adjust their binding sites to an antigen or receptor. Using Neutron Spin Echo Spectroscopy we observed fragment motion on a timescale of 7 ns with motional amplitudes of about 1 nm relative to each other. The mechanistic complexity of the linker region can be described by a spring model with Brownian motion of the fragments in a harmonic potential. Displacements, timescale, friction and force constant of the underlying dynamics are accessed. The force constant exhibits a similar strength to an entropic spring, with friction of the fragment matching the unbound state. The observed fast motions are fluctuations in pre-existing equilibrium configurations. The Brownian motion of domains in a harmonic potential is the appropriate model to examine functional hinge motions dependent on the structural topology and highlights the role of internal forces and friction to function. |
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