%0 Journal Article
%A Pinkawa, Michael
%A Brzozowska, Kinga
%A Kriehuber, Ralf
%A Eble, Michael J
%A Schmitz, Sabine
%T Prediction of radiation-induced toxicity by in vitro radiosensitivity of lymphocytes in prostate cancer patients
%J Future oncology
%V 12
%N 5
%@ 1744-8301
%C London
%I Future Medicine Ltd
%M FZJ-2016-02276
%P 617 - 624
%D 2016
%X Aim: To identify predictive assays for radiation-induced toxicity in prostate cancer patients.Patients & methods: Patients have been surveyed prospectively before and up to 16 monthsafter radiotherapy using a validated questionnaire. Subgroups of 25 patients with minorand larger score changes, respectively, were selected for γ-H2AX, G2 and Annexin V assays.Results: A significantly higher spontaneous chromatid aberration yield (HR: 1.46 [95% CI:1.02–2.09]; p = 0.04), higher levels of early apoptotic (HR: 1.12 [95% CI: 1.01–1.24]; p = 0.04) andlate apoptotic and necrotic (HR: 1.10 [95% CI: 0.99–1.23]; p = 0.08) lymphocytes 24-h postirradiationwere found in patients with a bowel bother score decrease greater than 20 pointsmore than 1 year after treatment. Conclusion: Chromatid aberration and apoptosis/necrosisassays appear to be suitable for the prediction of radiation-induced toxicity.
%F PUB:(DE-HGF)16
%9 Journal Article
%U <Go to ISI:>//WOS:000370695600008
%R 10.2217/fon.15.334
%U https://juser.fz-juelich.de/record/808538