Journal Article

FZJ-2016-02276

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Prediction of radiation-induced toxicity by in vitro radiosensitivity of lymphocytes in prostate cancer patients

Pinkawa, M. (Corresponding author) ; Brzozowska, K. ; Kriehuber, R.FZJ* ; Eble, M. J. ; Schmitz, S.FZJ*

2016
Future Medicine Ltd London

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Please use a persistent id in citations: doi:10.2217/fon.15.334

Abstract: Aim: To identify predictive assays for radiation-induced toxicity in prostate cancer patients.Patients & methods: Patients have been surveyed prospectively before and up to 16 monthsafter radiotherapy using a validated questionnaire. Subgroups of 25 patients with minorand larger score changes, respectively, were selected for γ-H2AX, G2 and Annexin V assays.Results: A significantly higher spontaneous chromatid aberration yield (HR: 1.46 [95% CI:1.02–2.09]; p = 0.04), higher levels of early apoptotic (HR: 1.12 [95% CI: 1.01–1.24]; p = 0.04) andlate apoptotic and necrotic (HR: 1.10 [95% CI: 0.99–1.23]; p = 0.08) lymphocytes 24-h postirradiationwere found in patients with a bowel bother score decrease greater than 20 pointsmore than 1 year after treatment. Conclusion: Chromatid aberration and apoptosis/necrosisassays appear to be suitable for the prediction of radiation-induced toxicity.

Keyword(s): Medicine (2nd)

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Contributing Institute(s):

1. Sicherheit und Strahlenschutz, Umgebungsüberwachung,Strahlenbiologie (S-US)

Research Program(s):

1. 899 - ohne Topic (POF3-899) (POF3-899)

Appears in the scientific report 2017

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Database coverage:
; Current Contents - Clinical Medicine ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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