TY  - JOUR
AU  - Pinkawa, Michael
AU  - Brzozowska, Kinga
AU  - Kriehuber, Ralf
AU  - Eble, Michael J
AU  - Schmitz, Sabine
TI  - Prediction of radiation-induced toxicity by in vitro radiosensitivity of lymphocytes in prostate cancer patients
JO  - Future oncology
VL  - 12
IS  - 5
SN  - 1744-8301
CY  - London
PB  - Future Medicine Ltd
M1  - FZJ-2016-02276
SP  - 617 - 624
PY  - 2016
AB  - Aim: To identify predictive assays for radiation-induced toxicity in prostate cancer patients.Patients & methods: Patients have been surveyed prospectively before and up to 16 monthsafter radiotherapy using a validated questionnaire. Subgroups of 25 patients with minorand larger score changes, respectively, were selected for γ-H2AX, G2 and Annexin V assays.Results: A significantly higher spontaneous chromatid aberration yield (HR: 1.46 [95% CI:1.02–2.09]; p = 0.04), higher levels of early apoptotic (HR: 1.12 [95% CI: 1.01–1.24]; p = 0.04) andlate apoptotic and necrotic (HR: 1.10 [95% CI: 0.99–1.23]; p = 0.08) lymphocytes 24-h postirradiationwere found in patients with a bowel bother score decrease greater than 20 pointsmore than 1 year after treatment. Conclusion: Chromatid aberration and apoptosis/necrosisassays appear to be suitable for the prediction of radiation-induced toxicity.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000370695600008
DO  - DOI:10.2217/fon.15.334
UR  - https://juser.fz-juelich.de/record/808538
ER  -