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@ARTICLE{Pinkawa:808538,
      author       = {Pinkawa, Michael and Brzozowska, Kinga and Kriehuber, Ralf
                      and Eble, Michael J and Schmitz, Sabine},
      title        = {{P}rediction of radiation-induced toxicity by in vitro
                      radiosensitivity of lymphocytes in prostate cancer patients},
      journal      = {Future oncology},
      volume       = {12},
      number       = {5},
      issn         = {1744-8301},
      address      = {London},
      publisher    = {Future Medicine Ltd},
      reportid     = {FZJ-2016-02276},
      pages        = {617 - 624},
      year         = {2016},
      abstract     = {Aim: To identify predictive assays for radiation-induced
                      toxicity in prostate cancer patients.Patients $\&$ methods:
                      Patients have been surveyed prospectively before and up to
                      16 monthsafter radiotherapy using a validated questionnaire.
                      Subgroups of 25 patients with minorand larger score changes,
                      respectively, were selected for γ-H2AX, G2 and Annexin V
                      assays.Results: A significantly higher spontaneous chromatid
                      aberration yield (HR: 1.46 $[95\%$ CI:1.02–2.09]; p =
                      0.04), higher levels of early apoptotic (HR: 1.12 $[95\%$
                      CI: 1.01–1.24]; p = 0.04) andlate apoptotic and necrotic
                      (HR: 1.10 $[95\%$ CI: 0.99–1.23]; p = 0.08) lymphocytes
                      24-h postirradiationwere found in patients with a bowel
                      bother score decrease greater than 20 pointsmore than 1 year
                      after treatment. Conclusion: Chromatid aberration and
                      apoptosis/necrosisassays appear to be suitable for the
                      prediction of radiation-induced toxicity.},
      cin          = {S-US},
      ddc          = {610},
      cid          = {I:(DE-Juel1)S-US-20090406},
      pnm          = {899 - ohne Topic (POF3-899)},
      pid          = {G:(DE-HGF)POF3-899},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000370695600008},
      doi          = {10.2217/fon.15.334},
      url          = {https://juser.fz-juelich.de/record/808538},
}