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@ARTICLE{Axer:808906,
author = {Axer, Markus and Strohmer, Sven and Gräßel, David and
Bücker, Oliver and Dohmen, Melanie and Reckfort, Julia and
Zilles, Karl and Amunts, Katrin},
title = {{E}stimating {F}iber {O}rientation {D}istribution
{F}unctions in 3{D}-{P}olarized {L}ight {I}maging},
journal = {Frontiers in neuroanatomy},
volume = {10},
issn = {1662-5129},
address = {Lausanne},
publisher = {Frontiers Research Foundation},
reportid = {FZJ-2016-02436},
pages = {40},
year = {2016},
abstract = {Research of the human brain connectome requires multiscale
approaches derived from independent imaging methods ideally
applied to the same object. Hence, comprehensible strategies
for data integration across modalities and across scales are
essential. We have successfully established a concept to
bridge the spatial scales from microscopic fiber orientation
measurements based on 3D-Polarized Light Imaging (3D-PLI) to
meso- or macroscopic dimensions. By creating orientation
distribution functions (pliODFs) from high-resolution vector
data via series expansion with spherical harmonics utilizing
high performance computing and supercomputing technologies,
data fusion with Diffusion Magnetic Resonance Imaging has
become feasible, even for a large-scale dataset such as the
human brain. Validation of our approach was done effectively
by means of two types of datasets that were transferred from
fiber orientation maps into pliODFs: simulated 3D-PLI data
showing artificial, but clearly defined fiber patterns and
real 3D-PLI data derived from sections through the human
brain and the brain of a hooded seal.},
cin = {INM-1 / JSC},
ddc = {610},
cid = {I:(DE-Juel1)INM-1-20090406 / I:(DE-Juel1)JSC-20090406},
pnm = {574 - Theory, modelling and simulation (POF3-574) / 511 -
Computational Science and Mathematical Methods (POF3-511) /
SMHB - Supercomputing and Modelling for the Human Brain
(HGF-SMHB-2013-2017) / HBP - The Human Brain Project
(604102) / NIH-R01MH092311 - Postnatal Development of
Cortical Receptors and White Matter Tracts in the Vervet
(NIH-R01MH092311) / SLNS - SimLab Neuroscience
(Helmholtz-SLNS)},
pid = {G:(DE-HGF)POF3-574 / G:(DE-HGF)POF3-511 /
G:(DE-Juel1)HGF-SMHB-2013-2017 / G:(EU-Grant)604102 /
G:(DE-Juel1)NIH-R01MH092311 / G:(DE-Juel1)Helmholtz-SLNS},
typ = {PUB:(DE-HGF)16},
UT = {WOS:000374307100001},
pubmed = {pmid:27147981},
doi = {10.3389/fnana.2016.00040},
url = {https://juser.fz-juelich.de/record/808906},
}